Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid

Daniel Neider, Leif H Lindström, Robert Bodén Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homo...

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Autores principales:	Neider D, Lindström LH, Bodén R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Key words: suicide schizophrenia bullying HVA 5-HIAA CSF Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/52929e5f313f46d294fbcddc02ae274a
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spelling	oai:doaj.org-article:52929e5f313f46d294fbcddc02ae274a2021-12-02T01:30:20ZRisk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid1178-2021https://doaj.org/article/52929e5f313f46d294fbcddc02ae274a2016-07-01T00:00:00Zhttps://www.dovepress.com/risk-factors-for-suicide-among-patients-with-schizophrenia-a-cohort-st-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Daniel Neider, Leif H Lindström, Robert Bodén Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia. Methods: Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated. Results: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05). Conclusion: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels. Keywords: psychosis, risk factors, bullying, HVA, 5-HIAA, CSFNeider DLindström LHBodén RDove Medical PressarticleKey words: suicideschizophreniabullyingHVA5-HIAACSFNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1711-1714 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Key words: suicide schizophrenia bullying HVA 5-HIAA CSF Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Key words: suicide schizophrenia bullying HVA 5-HIAA CSF Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neider D Lindström LH Bodén R Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
description	Daniel Neider, Leif H Lindström, Robert Bodén Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia. Methods: Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated. Results: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05). Conclusion: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels. Keywords: psychosis, risk factors, bullying, HVA, 5-HIAA, CSF
format	article
author	Neider D Lindström LH Bodén R
author_facet	Neider D Lindström LH Bodén R
author_sort	Neider D
title	Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
title_short	Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
title_full	Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
title_fullStr	Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
title_full_unstemmed	Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
title_sort	risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/52929e5f313f46d294fbcddc02ae274a
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Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid

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