Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

ABSTRACT Chronic lung infections with opportunistic bacterial and fungal pathogens are a major cause of morbidity and mortality especially in patients with cystic fibrosis. Pseudomonas aeruginosa is the most frequently colonizing bacterium in these patients, and it is often found in association with...

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Autores principales:	Benoit Briard, Christoph Heddergott, Jean-Paul Latgé
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/529543e64c774e1c80103acf5edb59e7
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spelling	oai:doaj.org-article:529543e64c774e1c80103acf5edb59e72021-11-15T15:41:42ZVolatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>10.1128/mBio.00219-162150-7511https://doaj.org/article/529543e64c774e1c80103acf5edb59e72016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00219-16https://doaj.org/toc/2150-7511ABSTRACT Chronic lung infections with opportunistic bacterial and fungal pathogens are a major cause of morbidity and mortality especially in patients with cystic fibrosis. Pseudomonas aeruginosa is the most frequently colonizing bacterium in these patients, and it is often found in association with the filamentous fungus Aspergillus fumigatus. P. aeruginosa is known to inhibit the growth of A. fumigatus in situations of direct contact, suggesting the existence of interspecies communication that may influence disease outcome. Our study shows that the lung pathogens P. aeruginosa and A. fumigatus can interact at a distance via volatile-mediated communication and expands our understanding of interspecific signaling in microbial communities. IMPORTANCE Microbiota studies have shown that pathogens cannot be studied individually anymore and that the establishment and progression of a specific disease are due not to a single microbial species but are the result of the activity of many species living together. To date, the interaction between members of the human microbiota has been analyzed in situations of direct contact or liquid-mediated contact between organisms. This study showed unexpectedly that human opportunistic pathogens can interact at a distance after sensing volatiles emitted by another microbial species. This finding will open a new research avenue for the understanding of microbial communities.Benoit BriardChristoph HeddergottJean-Paul LatgéAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Benoit Briard Christoph Heddergott Jean-Paul Latgé Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
description	ABSTRACT Chronic lung infections with opportunistic bacterial and fungal pathogens are a major cause of morbidity and mortality especially in patients with cystic fibrosis. Pseudomonas aeruginosa is the most frequently colonizing bacterium in these patients, and it is often found in association with the filamentous fungus Aspergillus fumigatus. P. aeruginosa is known to inhibit the growth of A. fumigatus in situations of direct contact, suggesting the existence of interspecies communication that may influence disease outcome. Our study shows that the lung pathogens P. aeruginosa and A. fumigatus can interact at a distance via volatile-mediated communication and expands our understanding of interspecific signaling in microbial communities. IMPORTANCE Microbiota studies have shown that pathogens cannot be studied individually anymore and that the establishment and progression of a specific disease are due not to a single microbial species but are the result of the activity of many species living together. To date, the interaction between members of the human microbiota has been analyzed in situations of direct contact or liquid-mediated contact between organisms. This study showed unexpectedly that human opportunistic pathogens can interact at a distance after sensing volatiles emitted by another microbial species. This finding will open a new research avenue for the understanding of microbial communities.
format	article
author	Benoit Briard Christoph Heddergott Jean-Paul Latgé
author_facet	Benoit Briard Christoph Heddergott Jean-Paul Latgé
author_sort	Benoit Briard
title	Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_short	Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_full	Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_fullStr	Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_full_unstemmed	Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_sort	volatile compounds emitted by <named-content content-type="genus-species">pseudomonas aeruginosa</named-content> stimulate growth of the fungal pathogen <named-content content-type="genus-species">aspergillus fumigatus</named-content>
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/529543e64c774e1c80103acf5edb59e7
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Volatile Compounds Emitted by <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Stimulate Growth of the Fungal Pathogen <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

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