Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature

Leopoldo Spadea, Emanuele Tonti, Enzo Maria Vingolo Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy Abstract: Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to str...

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Autores principales:	Spadea L, Tonti E, Vingolo EM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Corneal cross linking demarcation line keratoconus ultraviolet A Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5299b51825764757b21ff15337f98ad3
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spelling	oai:doaj.org-article:5299b51825764757b21ff15337f98ad32021-12-02T02:40:44ZCorneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature1177-5483https://doaj.org/article/5299b51825764757b21ff15337f98ad32016-09-01T00:00:00Zhttps://www.dovepress.com/corneal-stromal-demarcation-line-after-collagen-cross-linking-in-corne-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Leopoldo Spadea, Emanuele Tonti, Enzo Maria Vingolo Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy Abstract: Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds. Subjective and objective results following this method seem to be promising. In recent years, newer CXL protocols have been developed to perform more effective and less invasive procedures. The increasing diffusion of CXL in the corneal ectatic disease has increased the need to have actual indices regarding the efficacy of the treatment. Evaluation of demarcation line (DL), a transition zone between the cross-linked anterior corneal stroma and the untreated posterior corneal stroma, is considered a measurement of the depth of CXL treatment into the stroma. Some evidence in the literature emphasize that DL could be a measure of effectiveness of the CXL. On the contrary, some authors believe that the “the deeper, the better” principle is rather a simplistic approach for interpreting the clinical importance of the corneal stromal DL. Keywords: corneal cross-linking, demarcation line, keratoconus, ultraviolet ASpadea LTonti EVingolo EMDove Medical PressarticleCorneal cross linkingdemarcation linekeratoconusultraviolet AOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1803-1810 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Corneal cross linking demarcation line keratoconus ultraviolet A Ophthalmology RE1-994
spellingShingle	Corneal cross linking demarcation line keratoconus ultraviolet A Ophthalmology RE1-994 Spadea L Tonti E Vingolo EM Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
description	Leopoldo Spadea, Emanuele Tonti, Enzo Maria Vingolo Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy Abstract: Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds. Subjective and objective results following this method seem to be promising. In recent years, newer CXL protocols have been developed to perform more effective and less invasive procedures. The increasing diffusion of CXL in the corneal ectatic disease has increased the need to have actual indices regarding the efficacy of the treatment. Evaluation of demarcation line (DL), a transition zone between the cross-linked anterior corneal stroma and the untreated posterior corneal stroma, is considered a measurement of the depth of CXL treatment into the stroma. Some evidence in the literature emphasize that DL could be a measure of effectiveness of the CXL. On the contrary, some authors believe that the “the deeper, the better” principle is rather a simplistic approach for interpreting the clinical importance of the corneal stromal DL. Keywords: corneal cross-linking, demarcation line, keratoconus, ultraviolet A
format	article
author	Spadea L Tonti E Vingolo EM
author_facet	Spadea L Tonti E Vingolo EM
author_sort	Spadea L
title	Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
title_short	Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
title_full	Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
title_fullStr	Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
title_full_unstemmed	Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
title_sort	corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5299b51825764757b21ff15337f98ad3
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Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature

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