Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

Clusters of enhancers, called super-enhancers (SEs), control the expression of cell identity genes. Here, the authors identify two types of enhancer units within SEs in ESCs, characterised by distinctive CpG methylation dynamics, and find that ESRRB regulates the enhancer units decommissioned at exi...

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Autores principales:	Emma Bell, Edward W. Curry, Wout Megchelenbrink, Luc Jouneau, Vincent Brochard, Rute A. Tomaz, King Hang T. Mau, Yaser Atlasi, Roshni A. de Souza, Hendrik Marks, Hendrik G. Stunnenberg, Alice Jouneau, Véronique Azuara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5299ca445e9743b2869fc3fe2a1a17ce
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spelling	oai:doaj.org-article:5299ca445e9743b2869fc3fe2a1a17ce2021-12-02T14:40:40ZDynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency10.1038/s41467-020-14916-72041-1723https://doaj.org/article/5299ca445e9743b2869fc3fe2a1a17ce2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14916-7https://doaj.org/toc/2041-1723Clusters of enhancers, called super-enhancers (SEs), control the expression of cell identity genes. Here, the authors identify two types of enhancer units within SEs in ESCs, characterised by distinctive CpG methylation dynamics, and find that ESRRB regulates the enhancer units decommissioned at exit from naive pluripotency.Emma BellEdward W. CurryWout MegchelenbrinkLuc JouneauVincent BrochardRute A. TomazKing Hang T. MauYaser AtlasiRoshni A. de SouzaHendrik MarksHendrik G. StunnenbergAlice JouneauVéronique AzuaraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma Bell Edward W. Curry Wout Megchelenbrink Luc Jouneau Vincent Brochard Rute A. Tomaz King Hang T. Mau Yaser Atlasi Roshni A. de Souza Hendrik Marks Hendrik G. Stunnenberg Alice Jouneau Véronique Azuara Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
description	Clusters of enhancers, called super-enhancers (SEs), control the expression of cell identity genes. Here, the authors identify two types of enhancer units within SEs in ESCs, characterised by distinctive CpG methylation dynamics, and find that ESRRB regulates the enhancer units decommissioned at exit from naive pluripotency.
format	article
author	Emma Bell Edward W. Curry Wout Megchelenbrink Luc Jouneau Vincent Brochard Rute A. Tomaz King Hang T. Mau Yaser Atlasi Roshni A. de Souza Hendrik Marks Hendrik G. Stunnenberg Alice Jouneau Véronique Azuara
author_facet	Emma Bell Edward W. Curry Wout Megchelenbrink Luc Jouneau Vincent Brochard Rute A. Tomaz King Hang T. Mau Yaser Atlasi Roshni A. de Souza Hendrik Marks Hendrik G. Stunnenberg Alice Jouneau Véronique Azuara
author_sort	Emma Bell
title	Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
title_short	Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
title_full	Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
title_fullStr	Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
title_full_unstemmed	Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
title_sort	dynamic cpg methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5299ca445e9743b2869fc3fe2a1a17ce
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Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

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