Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.

<h4>Background</h4>Being born small for gestational age (SGA) is associated with decreased insulin sensitivity and increased blood pressure in childhood, but the association with clinical disease in early adulthood is less certain. The Danish Medical Birth Registry has registered all bir...

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Autores principales:	Rasmus á Rogvi, Rene Mathiasen, Gorm Greisen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/529a078ffbdb4dd7b04ebaccc9c99569
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id	oai:doaj.org-article:529a078ffbdb4dd7b04ebaccc9c99569
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spelling	oai:doaj.org-article:529a078ffbdb4dd7b04ebaccc9c995692021-11-18T06:59:29ZDefining smallness for gestational age in the early years of the Danish Medical Birth Registry.1932-620310.1371/journal.pone.0016668https://doaj.org/article/529a078ffbdb4dd7b04ebaccc9c995692011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21304958/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Being born small for gestational age (SGA) is associated with decreased insulin sensitivity and increased blood pressure in childhood, but the association with clinical disease in early adulthood is less certain. The Danish Medical Birth Registry has registered all births in Denmark since 1973, but due to variable data quality, data is most often used only from 1981 onwards, and birth registers in other countries may have similar problems for the early years. We wanted to examine whether the data can be used for identification of children born SGA and used in future research.<h4>Methodology/principal findings</h4>All persons born between 1974 and 1996 were identified in the Danish Medical Birth Registry (n = 1.704.890). Immigrants and children without data on gestational age and birth weight were excluded, and a total of 1.348.106 children were included in the analysis. The difference between the different variables used in the history of the registry were examined, and the quality of data in the birth registry from 1974-1981 was examined and compared to subsequent years. Data on birth weight and gestational age in the early years of the registry is inconsistent, and the identification of children born SGA is inaccurate, with 49% false-positives. The biggest source of error is due to the rough and inaccurate intervals used for gestational age. By using -3 standard deviations as a cut-off for the identification of children born SGA, the number of false-positives was reduced to 9%, while the amount of false-negatives were increased.<h4>Conclusion</h4>Choosing -3 standard deviations for identifying children born SGA is a viable, though not optimal solution for identifying children born SGA. Overall the data in the registry is of sufficient quality to be used in further medical research.Rasmus á RogviRene MathiasenGorm GreisenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e16668 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rasmus á Rogvi Rene Mathiasen Gorm Greisen Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.
description	<h4>Background</h4>Being born small for gestational age (SGA) is associated with decreased insulin sensitivity and increased blood pressure in childhood, but the association with clinical disease in early adulthood is less certain. The Danish Medical Birth Registry has registered all births in Denmark since 1973, but due to variable data quality, data is most often used only from 1981 onwards, and birth registers in other countries may have similar problems for the early years. We wanted to examine whether the data can be used for identification of children born SGA and used in future research.<h4>Methodology/principal findings</h4>All persons born between 1974 and 1996 were identified in the Danish Medical Birth Registry (n = 1.704.890). Immigrants and children without data on gestational age and birth weight were excluded, and a total of 1.348.106 children were included in the analysis. The difference between the different variables used in the history of the registry were examined, and the quality of data in the birth registry from 1974-1981 was examined and compared to subsequent years. Data on birth weight and gestational age in the early years of the registry is inconsistent, and the identification of children born SGA is inaccurate, with 49% false-positives. The biggest source of error is due to the rough and inaccurate intervals used for gestational age. By using -3 standard deviations as a cut-off for the identification of children born SGA, the number of false-positives was reduced to 9%, while the amount of false-negatives were increased.<h4>Conclusion</h4>Choosing -3 standard deviations for identifying children born SGA is a viable, though not optimal solution for identifying children born SGA. Overall the data in the registry is of sufficient quality to be used in further medical research.
format	article
author	Rasmus á Rogvi Rene Mathiasen Gorm Greisen
author_facet	Rasmus á Rogvi Rene Mathiasen Gorm Greisen
author_sort	Rasmus á Rogvi
title	Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.
title_short	Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.
title_full	Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.
title_fullStr	Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.
title_full_unstemmed	Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.
title_sort	defining smallness for gestational age in the early years of the danish medical birth registry.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/529a078ffbdb4dd7b04ebaccc9c99569
work_keys_str_mv	AT rasmusarogvi definingsmallnessforgestationalageintheearlyyearsofthedanishmedicalbirthregistry AT renemathiasen definingsmallnessforgestationalageintheearlyyearsofthedanishmedicalbirthregistry AT gormgreisen definingsmallnessforgestationalageintheearlyyearsofthedanishmedicalbirthregistry
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Defining smallness for gestational age in the early years of the Danish Medical Birth Registry.

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