Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age

Abstract In utero heat stress alters postnatal physiological and behavioral stress responses in pigs. However, the mechanisms underlying these alterations have not been determined. The study objective was to characterize the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat-str...

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Autores principales:	Jacob M. Maskal, Luiz F. Brito, Alan W. Duttlinger, Kouassi R. Kpodo, Betty R. McConn, Christopher J. Byrd, Brian T. Richert, Jeremy N. Marchant, Donald C. Lay, Shelbi D. Perry, Matthew C. Lucy, Tim J. Safranski, Jay S. Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/529bd7c954bf4fdfb64d89e7ec3aeeb5
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spelling	oai:doaj.org-article:529bd7c954bf4fdfb64d89e7ec3aeeb52021-11-21T12:23:12ZCharacterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age10.1038/s41598-021-01889-w2045-2322https://doaj.org/article/529bd7c954bf4fdfb64d89e7ec3aeeb52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01889-whttps://doaj.org/toc/2045-2322Abstract In utero heat stress alters postnatal physiological and behavioral stress responses in pigs. However, the mechanisms underlying these alterations have not been determined. The study objective was to characterize the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat-stressed pigs. Pigs were subjected to a dexamethasone suppression test followed by a corticotrophin releasing hormone challenge at 10 and 15 weeks of age. Following the challenge, hypothalamic, pituitary, and adrenal tissues were collected from all pigs for mRNA abundance analyses. At 10 weeks of age, in utero heat-stressed pigs had a reduced (P < 0.05) cortisol response to the corticotrophin releasing hormone challenge versus controls. Additionally, the cortisol response tended to be greater overall (P < 0.10) in 15 versus 10-week-old pigs in response to the dexamethasone suppression test. The cortisol response tended to be reduced overall (P < 0.10) in 15 versus 10-week-old pigs in response to the corticotrophin releasing hormone challenge. Hypothalamic corticotropin releasing hormone mRNA abundance tended to be greater (P < 0.10) in in utero heat-stressed versus control pigs at 15-weeks of age. In summary, in utero heat stress altered some aspects of the hypothalamic–pituitary–adrenal axis related to corticotropin releasing hormone signaling, and age influenced this response.Jacob M. MaskalLuiz F. BritoAlan W. DuttlingerKouassi R. KpodoBetty R. McConnChristopher J. ByrdBrian T. RichertJeremy N. MarchantDonald C. LayShelbi D. PerryMatthew C. LucyTim J. SafranskiJay S. JohnsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jacob M. Maskal Luiz F. Brito Alan W. Duttlinger Kouassi R. Kpodo Betty R. McConn Christopher J. Byrd Brian T. Richert Jeremy N. Marchant Donald C. Lay Shelbi D. Perry Matthew C. Lucy Tim J. Safranski Jay S. Johnson Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age
description	Abstract In utero heat stress alters postnatal physiological and behavioral stress responses in pigs. However, the mechanisms underlying these alterations have not been determined. The study objective was to characterize the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat-stressed pigs. Pigs were subjected to a dexamethasone suppression test followed by a corticotrophin releasing hormone challenge at 10 and 15 weeks of age. Following the challenge, hypothalamic, pituitary, and adrenal tissues were collected from all pigs for mRNA abundance analyses. At 10 weeks of age, in utero heat-stressed pigs had a reduced (P < 0.05) cortisol response to the corticotrophin releasing hormone challenge versus controls. Additionally, the cortisol response tended to be greater overall (P < 0.10) in 15 versus 10-week-old pigs in response to the dexamethasone suppression test. The cortisol response tended to be reduced overall (P < 0.10) in 15 versus 10-week-old pigs in response to the corticotrophin releasing hormone challenge. Hypothalamic corticotropin releasing hormone mRNA abundance tended to be greater (P < 0.10) in in utero heat-stressed versus control pigs at 15-weeks of age. In summary, in utero heat stress altered some aspects of the hypothalamic–pituitary–adrenal axis related to corticotropin releasing hormone signaling, and age influenced this response.
format	article
author	Jacob M. Maskal Luiz F. Brito Alan W. Duttlinger Kouassi R. Kpodo Betty R. McConn Christopher J. Byrd Brian T. Richert Jeremy N. Marchant Donald C. Lay Shelbi D. Perry Matthew C. Lucy Tim J. Safranski Jay S. Johnson
author_facet	Jacob M. Maskal Luiz F. Brito Alan W. Duttlinger Kouassi R. Kpodo Betty R. McConn Christopher J. Byrd Brian T. Richert Jeremy N. Marchant Donald C. Lay Shelbi D. Perry Matthew C. Lucy Tim J. Safranski Jay S. Johnson
author_sort	Jacob M. Maskal
title	Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age
title_short	Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age
title_full	Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age
title_fullStr	Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age
title_full_unstemmed	Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age
title_sort	characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/529bd7c954bf4fdfb64d89e7ec3aeeb5
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Characterizing the postnatal hypothalamic–pituitary–adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age

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