Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.

<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD), a common chronic liver disease, may progress to fibrosis, cirrhosis, hepatocellular carcinoma, and liver failure. But only a few cross-sectional studies have reported an association of NAFLD with working hours. This cohort stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yesung Lee, Eunchan Mun, Soyoung Park, Woncheol Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/52a388f6287a4262b68986c78faae140
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:52a388f6287a4262b68986c78faae140
record_format	dspace
spelling	oai:doaj.org-article:52a388f6287a4262b68986c78faae1402021-12-02T20:06:31ZLong working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.1932-620310.1371/journal.pone.0255118https://doaj.org/article/52a388f6287a4262b68986c78faae1402021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255118https://doaj.org/toc/1932-6203<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD), a common chronic liver disease, may progress to fibrosis, cirrhosis, hepatocellular carcinoma, and liver failure. But only a few cross-sectional studies have reported an association of NAFLD with working hours. This cohort study further examined the association between working hours and the development of NAFLD.<h4>Methods</h4>We included 79,048 Korean adults without NAFLD at baseline who underwent a comprehensive health examination and categorized weekly working hours into 35-40, 41-52, 53-60, and >60 hours. NAFLD was defined as the presence of fatty liver, in the absence of excessive alcohol use, as observed by ultrasound.<h4>Results</h4>During a median follow-up of 6.6 years, 15,095 participants developed new-onset NAFLD (incidence rate, 5.55 per 100 person-years). After adjustment for confounders, the hazard ratios (95% confidence interval) for the development of NAFLD in 41-52, 53-60, and >60 working hours compared with that in 35-40 working hours were 1.07 (1.02-1.13), 1.06 (1.00-1.13), and 1.13 (1.05-1.23), respectively. Furthermore, the association remained significant after confounders were treated as time-varying covariates.<h4>Conclusion</h4>In this large-scale cohort, long working hours, especially >60 working hours a week, were independently associated with incident NAFLD. Our findings indicate that long working hours are a risk factor for NAFLD.Yesung LeeEunchan MunSoyoung ParkWoncheol LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255118 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yesung Lee Eunchan Mun Soyoung Park Woncheol Lee Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.
description	<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD), a common chronic liver disease, may progress to fibrosis, cirrhosis, hepatocellular carcinoma, and liver failure. But only a few cross-sectional studies have reported an association of NAFLD with working hours. This cohort study further examined the association between working hours and the development of NAFLD.<h4>Methods</h4>We included 79,048 Korean adults without NAFLD at baseline who underwent a comprehensive health examination and categorized weekly working hours into 35-40, 41-52, 53-60, and >60 hours. NAFLD was defined as the presence of fatty liver, in the absence of excessive alcohol use, as observed by ultrasound.<h4>Results</h4>During a median follow-up of 6.6 years, 15,095 participants developed new-onset NAFLD (incidence rate, 5.55 per 100 person-years). After adjustment for confounders, the hazard ratios (95% confidence interval) for the development of NAFLD in 41-52, 53-60, and >60 working hours compared with that in 35-40 working hours were 1.07 (1.02-1.13), 1.06 (1.00-1.13), and 1.13 (1.05-1.23), respectively. Furthermore, the association remained significant after confounders were treated as time-varying covariates.<h4>Conclusion</h4>In this large-scale cohort, long working hours, especially >60 working hours a week, were independently associated with incident NAFLD. Our findings indicate that long working hours are a risk factor for NAFLD.
format	article
author	Yesung Lee Eunchan Mun Soyoung Park Woncheol Lee
author_facet	Yesung Lee Eunchan Mun Soyoung Park Woncheol Lee
author_sort	Yesung Lee
title	Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.
title_short	Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.
title_full	Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.
title_fullStr	Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.
title_full_unstemmed	Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.
title_sort	long working hours are associated with a higher risk of non-alcoholic fatty liver disease: a large population-based korean cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/52a388f6287a4262b68986c78faae140
work_keys_str_mv	AT yesunglee longworkinghoursareassociatedwithahigherriskofnonalcoholicfattyliverdiseasealargepopulationbasedkoreancohortstudy AT eunchanmun longworkinghoursareassociatedwithahigherriskofnonalcoholicfattyliverdiseasealargepopulationbasedkoreancohortstudy AT soyoungpark longworkinghoursareassociatedwithahigherriskofnonalcoholicfattyliverdiseasealargepopulationbasedkoreancohortstudy AT woncheollee longworkinghoursareassociatedwithahigherriskofnonalcoholicfattyliverdiseasealargepopulationbasedkoreancohortstudy
_version_	1718375359980765184

Long working hours are associated with a higher risk of non-alcoholic fatty liver disease: A large population-based Korean cohort study.

Ejemplares similares