ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan

Mutations in genes required for the glycosylation of α-dystroglycan lead to dystroglycanopathies. Here, the authors show that three of these enzymes (ISPD, FKTN and FKRP) work together to attach ribitol phosphate to α-dystroglycan.

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Autores principales:	Isabelle Gerin, Benoît Ury, Isabelle Breloy, Céline Bouchet-Seraphin, Jennifer Bolsée, Mathias Halbout, Julie Graff, Didier Vertommen, Giulio G. Muccioli, Nathalie Seta, Jean-Marie Cuisset, Ivana Dabaj, Susana Quijano-Roy, Ammi Grahn, Emile Van Schaftingen, Guido T. Bommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52a41f70e28942c9b6bfb5d64d331efc
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spelling	oai:doaj.org-article:52a41f70e28942c9b6bfb5d64d331efc2021-12-02T15:35:00ZISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan10.1038/ncomms115342041-1723https://doaj.org/article/52a41f70e28942c9b6bfb5d64d331efc2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11534https://doaj.org/toc/2041-1723Mutations in genes required for the glycosylation of α-dystroglycan lead to dystroglycanopathies. Here, the authors show that three of these enzymes (ISPD, FKTN and FKRP) work together to attach ribitol phosphate to α-dystroglycan.Isabelle GerinBenoît UryIsabelle BreloyCéline Bouchet-SeraphinJennifer BolséeMathias HalboutJulie GraffDidier VertommenGiulio G. MuccioliNathalie SetaJean-Marie CuissetIvana DabajSusana Quijano-RoyAmmi GrahnEmile Van SchaftingenGuido T. BommerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabelle Gerin Benoît Ury Isabelle Breloy Céline Bouchet-Seraphin Jennifer Bolsée Mathias Halbout Julie Graff Didier Vertommen Giulio G. Muccioli Nathalie Seta Jean-Marie Cuisset Ivana Dabaj Susana Quijano-Roy Ammi Grahn Emile Van Schaftingen Guido T. Bommer ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan
description	Mutations in genes required for the glycosylation of α-dystroglycan lead to dystroglycanopathies. Here, the authors show that three of these enzymes (ISPD, FKTN and FKRP) work together to attach ribitol phosphate to α-dystroglycan.
format	article
author	Isabelle Gerin Benoît Ury Isabelle Breloy Céline Bouchet-Seraphin Jennifer Bolsée Mathias Halbout Julie Graff Didier Vertommen Giulio G. Muccioli Nathalie Seta Jean-Marie Cuisset Ivana Dabaj Susana Quijano-Roy Ammi Grahn Emile Van Schaftingen Guido T. Bommer
author_facet	Isabelle Gerin Benoît Ury Isabelle Breloy Céline Bouchet-Seraphin Jennifer Bolsée Mathias Halbout Julie Graff Didier Vertommen Giulio G. Muccioli Nathalie Seta Jean-Marie Cuisset Ivana Dabaj Susana Quijano-Roy Ammi Grahn Emile Van Schaftingen Guido T. Bommer
author_sort	Isabelle Gerin
title	ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan
title_short	ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan
title_full	ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan
title_fullStr	ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan
title_full_unstemmed	ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan
title_sort	ispd produces cdp-ribitol used by fktn and fkrp to transfer ribitol phosphate onto α-dystroglycan
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/52a41f70e28942c9b6bfb5d64d331efc
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ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan

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