Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo

Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.

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Autores principales:	S. Dong, C. Aguirre-Hernandez, A. Scrivo, C. Eliscovich, E. Arias, J. J. Bravo-Cordero, A. M. Cuervo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52a95517e904406cabfd76804cb315b6
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spelling	oai:doaj.org-article:52a95517e904406cabfd76804cb315b62021-12-02T17:31:57ZMonitoring spatiotemporal changes in chaperone-mediated autophagy in vivo10.1038/s41467-019-14164-42041-1723https://doaj.org/article/52a95517e904406cabfd76804cb315b62020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14164-4https://doaj.org/toc/2041-1723Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.S. DongC. Aguirre-HernandezA. ScrivoC. EliscovichE. AriasJ. J. Bravo-CorderoA. M. CuervoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Dong C. Aguirre-Hernandez A. Scrivo C. Eliscovich E. Arias J. J. Bravo-Cordero A. M. Cuervo Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
description	Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.
format	article
author	S. Dong C. Aguirre-Hernandez A. Scrivo C. Eliscovich E. Arias J. J. Bravo-Cordero A. M. Cuervo
author_facet	S. Dong C. Aguirre-Hernandez A. Scrivo C. Eliscovich E. Arias J. J. Bravo-Cordero A. M. Cuervo
author_sort	S. Dong
title	Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
title_short	Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
title_full	Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
title_fullStr	Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
title_full_unstemmed	Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
title_sort	monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/52a95517e904406cabfd76804cb315b6
work_keys_str_mv	AT sdong monitoringspatiotemporalchangesinchaperonemediatedautophagyinvivo AT caguirrehernandez monitoringspatiotemporalchangesinchaperonemediatedautophagyinvivo AT ascrivo monitoringspatiotemporalchangesinchaperonemediatedautophagyinvivo AT celiscovich monitoringspatiotemporalchangesinchaperonemediatedautophagyinvivo AT earias monitoringspatiotemporalchangesinchaperonemediatedautophagyinvivo AT jjbravocordero monitoringspatiotemporalchangesinchaperonemediatedautophagyinvivo AT amcuervo monitoringspatiotemporalchangesinchaperonemediatedautophagyinvivo
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Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo

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