Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo

Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.

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Autores principales: S. Dong, C. Aguirre-Hernandez, A. Scrivo, C. Eliscovich, E. Arias, J. J. Bravo-Cordero, A. M. Cuervo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/52a95517e904406cabfd76804cb315b6
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