PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation

The proteins of the chromosomal passenger complex help chromosomes condense before cell division, but how this complex arrives at chromosomes was not known. Here the authors show that PRMT6 methylates histone H3 to recruit the chromosomal passenger complex.

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Autores principales: Seul Kim, Nam Hyun Kim, Ji Eun Park, Jee Won Hwang, Nayeon Myung, Ki-Tae Hwang, Young A Kim, Chang-Young Jang, Yong Kee Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/52a9c7201c7749b99216d7854cd4a940
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Sumario:The proteins of the chromosomal passenger complex help chromosomes condense before cell division, but how this complex arrives at chromosomes was not known. Here the authors show that PRMT6 methylates histone H3 to recruit the chromosomal passenger complex.