Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score

Introduction: The Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) and Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS), with the EULAR-OMERACT-2005 MR-Atlas, demonstrate characteristics and lesion degrees (synovitis, erosions, bone marrow edema [BME]) in rheumatoid a...

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Autores principales:	M. del Carmen Larios-Forte, Mario A. Garza-Elizondo, Cassandra M. Skinner-Taylor, Jorge A. Esquivel-Valerio, David Vega-Morales, Dionicio A. Galarza-Delgado, Diana E. Flores-Alvarado, Rodrigo E. Elizondo-Omaña, Alejandro Quiroga-Garza
Formato:	article
Lenguaje:	EN ES
Publicado:	Permanyer 2021
Materias:	Rheumatoid arthritis. Magnetic resonance imaging. Outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score. Extended rheumatoid arthritis magnetic resonance imaging score. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/52abd07d7857434ca128cfce3c1838ea
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spelling	oai:doaj.org-article:52abd07d7857434ca128cfce3c1838ea2021-11-04T01:12:20ZRheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score10.24875/RMU.210000021665-57962530-0709https://doaj.org/article/52abd07d7857434ca128cfce3c1838ea2021-04-01T00:00:00Zhttps://www.medicinauniversitaria.org/frame_esp.php?id=126https://doaj.org/toc/1665-5796https://doaj.org/toc/2530-0709Introduction: The Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) and Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS), with the EULAR-OMERACT-2005 MR-Atlas, demonstrate characteristics and lesion degrees (synovitis, erosions, bone marrow edema [BME]) in rheumatoid arthritis (R.A.) clinical diagnosis for follow-up and treatment response. Our study’s objective was to use RAMRIS in patients from three R.A. phases to detect lesions according to their tissue characterization (fluid levels in tissue) using different magnetic resonance imaging (MRI) sequences. Methods: Sixty contrast-enhanced MRIs from R.A. patients (clinical suspect arthralgia [CSA] – 38%, early R.A. [ERA] – 37%, and established [R.A.] – 25%) were evaluated according to the American College of Rheumatology (ACR-EULAR)-2010 criteria. R.A. lesions evaluation was performed with RAMRIS/Atlas/scoring; our analysis added the presence of lesions in the thumb and wrist (tenosynovitis, synovitis, erosions, and BME), proposing an “extended RAMRIS.” Results: Overall, 83% (50/60) women, mean 42 ± 13.5 (19-70) years-of-age, from 1731 evaluated sites, 964 lesions were identified. Synovitis 46% (445/964) was most frequently found in the carpal bones 72% (321/445). Extended RAMRIS demonstrated tenosynovitis and erosions in 1st carpometacarpal, 1st metacarpophalangeal, and hand-wrist tenosynovitis. Gadolinium contrast showed synovial and erosions enhancement indicating active lesions, most predominantly in ERA. Conclusions: Extended RAMRIS score was not statistically different (p = 0.43) from RAMRIS-2005. However, it considers all hand-wrist bone joint sites and tendon lesions needed for assessing a more accurate degree of disease development. A proposed extended RAMRIS should be considered. M. del Carmen Larios-ForteMario A. Garza-ElizondoCassandra M. Skinner-TaylorJorge A. Esquivel-ValerioDavid Vega-MoralesDionicio A. Galarza-DelgadoDiana E. Flores-AlvaradoRodrigo E. Elizondo-OmañaAlejandro Quiroga-GarzaPermanyerarticleRheumatoid arthritis. Magnetic resonance imaging. Outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score. Extended rheumatoid arthritis magnetic resonance imaging score.Medicine (General)R5-920ENESMedicina Universitaria, Vol 23, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN ES
topic	Rheumatoid arthritis. Magnetic resonance imaging. Outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score. Extended rheumatoid arthritis magnetic resonance imaging score. Medicine (General) R5-920
spellingShingle	Rheumatoid arthritis. Magnetic resonance imaging. Outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score. Extended rheumatoid arthritis magnetic resonance imaging score. Medicine (General) R5-920 M. del Carmen Larios-Forte Mario A. Garza-Elizondo Cassandra M. Skinner-Taylor Jorge A. Esquivel-Valerio David Vega-Morales Dionicio A. Galarza-Delgado Diana E. Flores-Alvarado Rodrigo E. Elizondo-Omaña Alejandro Quiroga-Garza Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score
description	Introduction: The Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) and Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS), with the EULAR-OMERACT-2005 MR-Atlas, demonstrate characteristics and lesion degrees (synovitis, erosions, bone marrow edema [BME]) in rheumatoid arthritis (R.A.) clinical diagnosis for follow-up and treatment response. Our study’s objective was to use RAMRIS in patients from three R.A. phases to detect lesions according to their tissue characterization (fluid levels in tissue) using different magnetic resonance imaging (MRI) sequences. Methods: Sixty contrast-enhanced MRIs from R.A. patients (clinical suspect arthralgia [CSA] – 38%, early R.A. [ERA] – 37%, and established [R.A.] – 25%) were evaluated according to the American College of Rheumatology (ACR-EULAR)-2010 criteria. R.A. lesions evaluation was performed with RAMRIS/Atlas/scoring; our analysis added the presence of lesions in the thumb and wrist (tenosynovitis, synovitis, erosions, and BME), proposing an “extended RAMRIS.” Results: Overall, 83% (50/60) women, mean 42 ± 13.5 (19-70) years-of-age, from 1731 evaluated sites, 964 lesions were identified. Synovitis 46% (445/964) was most frequently found in the carpal bones 72% (321/445). Extended RAMRIS demonstrated tenosynovitis and erosions in 1st carpometacarpal, 1st metacarpophalangeal, and hand-wrist tenosynovitis. Gadolinium contrast showed synovial and erosions enhancement indicating active lesions, most predominantly in ERA. Conclusions: Extended RAMRIS score was not statistically different (p = 0.43) from RAMRIS-2005. However, it considers all hand-wrist bone joint sites and tendon lesions needed for assessing a more accurate degree of disease development. A proposed extended RAMRIS should be considered.
format	article
author	M. del Carmen Larios-Forte Mario A. Garza-Elizondo Cassandra M. Skinner-Taylor Jorge A. Esquivel-Valerio David Vega-Morales Dionicio A. Galarza-Delgado Diana E. Flores-Alvarado Rodrigo E. Elizondo-Omaña Alejandro Quiroga-Garza
author_facet	M. del Carmen Larios-Forte Mario A. Garza-Elizondo Cassandra M. Skinner-Taylor Jorge A. Esquivel-Valerio David Vega-Morales Dionicio A. Galarza-Delgado Diana E. Flores-Alvarado Rodrigo E. Elizondo-Omaña Alejandro Quiroga-Garza
author_sort	M. del Carmen Larios-Forte
title	Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score
title_short	Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score
title_full	Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score
title_fullStr	Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score
title_full_unstemmed	Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score
title_sort	rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score
publisher	Permanyer
publishDate	2021
url	https://doaj.org/article/52abd07d7857434ca128cfce3c1838ea
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Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score

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