Antioxidant Effect of Melatonin in Preterm Newborns

Introduction. Preterm infants are at risk of free radical-mediated diseases from oxidative stress (OS) injury. Increased free radical generation has been demonstrated in preterm infants during the first seven days of life. Melatonin (MEL) is a powerful antioxidant and scavenger of free radicals. In...

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Autores principales:	Lucia Marseglia, Eloisa Gitto, Elisa Laschi, Maurizio Giordano, Carmelo Romeo, Laura Cannavò, Anna Laura Toni, Giuseppe Buonocore, Serafina Perrone
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/52aed5f5dff340be949b9187293eefe7
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spelling	oai:doaj.org-article:52aed5f5dff340be949b9187293eefe72021-11-29T00:57:06ZAntioxidant Effect of Melatonin in Preterm Newborns1942-099410.1155/2021/6308255https://doaj.org/article/52aed5f5dff340be949b9187293eefe72021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6308255https://doaj.org/toc/1942-0994Introduction. Preterm infants are at risk of free radical-mediated diseases from oxidative stress (OS) injury. Increased free radical generation has been demonstrated in preterm infants during the first seven days of life. Melatonin (MEL) is a powerful antioxidant and scavenger of free radicals. In preterm neonates, melatonin deficiency has been reported. Exogenous melatonin administration appears a promising strategy in the treatment of neonatal morbidities in which OS has a leading role. Objective. The aim was to evaluate plasma MEL concentrations and OS biomarkers in preterm newborns after early administration of melatonin. Methods. A prospective, randomized double-blind placebo-controlled pilot study was conducted from January 2019 to September 2020. Thirty-six preterm newborns were enrolled. Starting from the first day of life, 21 received a single dose of oral melatonin 0.5 mg/kg once a day, in the morning (MEL group); 15 newborns received an equivalent dose of placebo (placebo group). Samples of 0.2 mL of plasma were collected at 24 and 48 hours after MEL administration. Plasma concentrations of melatonin, non-protein-bound iron (NPBI), advanced oxidation protein products (AOPP), and F2-isoprostanes (F2-Isopr) were measured. Babies were clinically followed until discharge. Results. At 24 and 48 hours after MEL administration, the MEL concentrations were significantly higher in the MEL group than in the placebo group (52759.30±63529.09 vs. 28.57±46.24 pg/mL and 279397.6±516344.2 vs. 38.50±44.01 pg/mL, respectively). NPBI and AOPP did not show any statistically significant differences between the groups both at 24 and 48 hours. At 48 hours, the mean blood concentrations of F2-Isopr were significantly lower in the MEL group than in the placebo group (36.48±33.85 pg/mL vs.89.97±52.01 pg/mL). Conclusions. Early melatonin administration in preterm newborns reduces lipid peroxidation in the first days of life showing a potential role to protect high-risk newborns. Trial Registration. This trial is registered with NCT04785183, Early Supplementation of Melatonin in Preterm Newborns: the Effects on Oxidative Stress.Lucia MarsegliaEloisa GittoElisa LaschiMaurizio GiordanoCarmelo RomeoLaura CannavòAnna Laura ToniGiuseppe BuonocoreSerafina PerroneHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Lucia Marseglia Eloisa Gitto Elisa Laschi Maurizio Giordano Carmelo Romeo Laura Cannavò Anna Laura Toni Giuseppe Buonocore Serafina Perrone Antioxidant Effect of Melatonin in Preterm Newborns
description	Introduction. Preterm infants are at risk of free radical-mediated diseases from oxidative stress (OS) injury. Increased free radical generation has been demonstrated in preterm infants during the first seven days of life. Melatonin (MEL) is a powerful antioxidant and scavenger of free radicals. In preterm neonates, melatonin deficiency has been reported. Exogenous melatonin administration appears a promising strategy in the treatment of neonatal morbidities in which OS has a leading role. Objective. The aim was to evaluate plasma MEL concentrations and OS biomarkers in preterm newborns after early administration of melatonin. Methods. A prospective, randomized double-blind placebo-controlled pilot study was conducted from January 2019 to September 2020. Thirty-six preterm newborns were enrolled. Starting from the first day of life, 21 received a single dose of oral melatonin 0.5 mg/kg once a day, in the morning (MEL group); 15 newborns received an equivalent dose of placebo (placebo group). Samples of 0.2 mL of plasma were collected at 24 and 48 hours after MEL administration. Plasma concentrations of melatonin, non-protein-bound iron (NPBI), advanced oxidation protein products (AOPP), and F2-isoprostanes (F2-Isopr) were measured. Babies were clinically followed until discharge. Results. At 24 and 48 hours after MEL administration, the MEL concentrations were significantly higher in the MEL group than in the placebo group (52759.30±63529.09 vs. 28.57±46.24 pg/mL and 279397.6±516344.2 vs. 38.50±44.01 pg/mL, respectively). NPBI and AOPP did not show any statistically significant differences between the groups both at 24 and 48 hours. At 48 hours, the mean blood concentrations of F2-Isopr were significantly lower in the MEL group than in the placebo group (36.48±33.85 pg/mL vs.89.97±52.01 pg/mL). Conclusions. Early melatonin administration in preterm newborns reduces lipid peroxidation in the first days of life showing a potential role to protect high-risk newborns. Trial Registration. This trial is registered with NCT04785183, Early Supplementation of Melatonin in Preterm Newborns: the Effects on Oxidative Stress.
format	article
author	Lucia Marseglia Eloisa Gitto Elisa Laschi Maurizio Giordano Carmelo Romeo Laura Cannavò Anna Laura Toni Giuseppe Buonocore Serafina Perrone
author_facet	Lucia Marseglia Eloisa Gitto Elisa Laschi Maurizio Giordano Carmelo Romeo Laura Cannavò Anna Laura Toni Giuseppe Buonocore Serafina Perrone
author_sort	Lucia Marseglia
title	Antioxidant Effect of Melatonin in Preterm Newborns
title_short	Antioxidant Effect of Melatonin in Preterm Newborns
title_full	Antioxidant Effect of Melatonin in Preterm Newborns
title_fullStr	Antioxidant Effect of Melatonin in Preterm Newborns
title_full_unstemmed	Antioxidant Effect of Melatonin in Preterm Newborns
title_sort	antioxidant effect of melatonin in preterm newborns
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/52aed5f5dff340be949b9187293eefe7
work_keys_str_mv	AT luciamarseglia antioxidanteffectofmelatonininpretermnewborns AT eloisagitto antioxidanteffectofmelatonininpretermnewborns AT elisalaschi antioxidanteffectofmelatonininpretermnewborns AT mauriziogiordano antioxidanteffectofmelatonininpretermnewborns AT carmeloromeo antioxidanteffectofmelatonininpretermnewborns AT lauracannavo antioxidanteffectofmelatonininpretermnewborns AT annalauratoni antioxidanteffectofmelatonininpretermnewborns AT giuseppebuonocore antioxidanteffectofmelatonininpretermnewborns AT serafinaperrone antioxidanteffectofmelatonininpretermnewborns
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Antioxidant Effect of Melatonin in Preterm Newborns

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