Tear Film Characteristics During Wear of Daily Disposable Contact Lenses

Giancarlo Montani, Maurizio Martino Dipartimento di Matematica e Fisica “Ennio De Giorgi”, CERCA Università del Salento, Lecce, ItalyCorrespondence: Giancarlo MontaniDipartimento di Matematica e Fisica “Ennio De Giorgi”, CERCA Università...

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Autores principales:	Montani G, Martino M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nesofilcon a delefilcon a stenfilcon a quality of vision pre-lens tear film stability tear osmolarity tear meniscus height Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/52b0fdcd9284403eb1fb037c094c8251
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spelling	oai:doaj.org-article:52b0fdcd9284403eb1fb037c094c82512021-12-02T08:36:24ZTear Film Characteristics During Wear of Daily Disposable Contact Lenses1177-5483https://doaj.org/article/52b0fdcd9284403eb1fb037c094c82512020-06-01T00:00:00Zhttps://www.dovepress.com/tear-film-characteristics-during-wear-of-daily-disposable-contact-lens-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Giancarlo Montani, Maurizio Martino Dipartimento di Matematica e Fisica “Ennio De Giorgi”, CERCA Università del Salento, Lecce, ItalyCorrespondence: Giancarlo MontaniDipartimento di Matematica e Fisica “Ennio De Giorgi”, CERCA Università del Salento, Via per Arnesano, Lecce 73100, ItalyEmail giancarlo.montani@le.infn.itPurpose: To evaluate changes induced over time by three daily disposable (DD) contact lenses on tear meniscus height (TMH), pre-lens non-invasive break-up time (pre-lens NIBUT), tear film osmolarity (TO) and objective quality of vision (OQV).Patients and Methods: Forty-six subjects enrolled in this prospective open-label unmasked non-randomized simultaneous comparative cross-over study. For the first week of the study, subjects wore a nesofilcon A lens in the right eye and a delefilcon A lens in the left eye. After 3 days of washout, for the second week, subjects wore a nesofilcon A lens in the left eye and a stenfilcon A lens in the right eye. TMH, pre-lens NIBUT, TO and OQV were measured before contact lens fitting and for each contact lens combination on day 1 at 20 minutes and on day 7 after ≥ 8 hours of wear. OQV measurement included the changes of objective scatter index (OSI), the stability index (SI) and the fluctuation index (FI) calculated in a range of time of 20 s from a blink.Results: TMH was unchanged at 20 minutes wear of all lenses but was significantly reduced after 8 or more hours wear (on day 7) of delefilcon A and stenfilcon A, respectively. Pre-lens NIBUT was significantly reduced with all lenses, while no significant change in TO was observed with any lens. SI and FI increased significantly for all lenses at both wear times.Conclusion: While the presence of any contact lens on the eye challenges the tear film, nesofilcon A contact lenses, despite their high water content, compared to delefilcon A and stenfilcon A contact lenses, showed a lower overall effect. We speculate that superior tear film behavior while wearing nesofilcon A lenses may translate to improved subjective comfort, but this remains to be evaluated.Keywords: nesofilcon A, delefilcon A, stenfilcon A, quality of vision, pre-lens tear film stability, tear osmolarity, tear meniscus heightMontani GMartino MDove Medical Pressarticlenesofilcon adelefilcon astenfilcon aquality of visionpre-lens tear film stabilitytear osmolaritytear meniscus heightOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1521-1531 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nesofilcon a delefilcon a stenfilcon a quality of vision pre-lens tear film stability tear osmolarity tear meniscus height Ophthalmology RE1-994
spellingShingle	nesofilcon a delefilcon a stenfilcon a quality of vision pre-lens tear film stability tear osmolarity tear meniscus height Ophthalmology RE1-994 Montani G Martino M Tear Film Characteristics During Wear of Daily Disposable Contact Lenses
description	Giancarlo Montani, Maurizio Martino Dipartimento di Matematica e Fisica “Ennio De Giorgi”, CERCA Università del Salento, Lecce, ItalyCorrespondence: Giancarlo MontaniDipartimento di Matematica e Fisica “Ennio De Giorgi”, CERCA Università del Salento, Via per Arnesano, Lecce 73100, ItalyEmail giancarlo.montani@le.infn.itPurpose: To evaluate changes induced over time by three daily disposable (DD) contact lenses on tear meniscus height (TMH), pre-lens non-invasive break-up time (pre-lens NIBUT), tear film osmolarity (TO) and objective quality of vision (OQV).Patients and Methods: Forty-six subjects enrolled in this prospective open-label unmasked non-randomized simultaneous comparative cross-over study. For the first week of the study, subjects wore a nesofilcon A lens in the right eye and a delefilcon A lens in the left eye. After 3 days of washout, for the second week, subjects wore a nesofilcon A lens in the left eye and a stenfilcon A lens in the right eye. TMH, pre-lens NIBUT, TO and OQV were measured before contact lens fitting and for each contact lens combination on day 1 at 20 minutes and on day 7 after ≥ 8 hours of wear. OQV measurement included the changes of objective scatter index (OSI), the stability index (SI) and the fluctuation index (FI) calculated in a range of time of 20 s from a blink.Results: TMH was unchanged at 20 minutes wear of all lenses but was significantly reduced after 8 or more hours wear (on day 7) of delefilcon A and stenfilcon A, respectively. Pre-lens NIBUT was significantly reduced with all lenses, while no significant change in TO was observed with any lens. SI and FI increased significantly for all lenses at both wear times.Conclusion: While the presence of any contact lens on the eye challenges the tear film, nesofilcon A contact lenses, despite their high water content, compared to delefilcon A and stenfilcon A contact lenses, showed a lower overall effect. We speculate that superior tear film behavior while wearing nesofilcon A lenses may translate to improved subjective comfort, but this remains to be evaluated.Keywords: nesofilcon A, delefilcon A, stenfilcon A, quality of vision, pre-lens tear film stability, tear osmolarity, tear meniscus height
format	article
author	Montani G Martino M
author_facet	Montani G Martino M
author_sort	Montani G
title	Tear Film Characteristics During Wear of Daily Disposable Contact Lenses
title_short	Tear Film Characteristics During Wear of Daily Disposable Contact Lenses
title_full	Tear Film Characteristics During Wear of Daily Disposable Contact Lenses
title_fullStr	Tear Film Characteristics During Wear of Daily Disposable Contact Lenses
title_full_unstemmed	Tear Film Characteristics During Wear of Daily Disposable Contact Lenses
title_sort	tear film characteristics during wear of daily disposable contact lenses
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/52b0fdcd9284403eb1fb037c094c8251
work_keys_str_mv	AT montanig tearfilmcharacteristicsduringwearofdailydisposablecontactlenses AT martinom tearfilmcharacteristicsduringwearofdailydisposablecontactlenses
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Tear Film Characteristics During Wear of Daily Disposable Contact Lenses

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