Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes

This study aimed to investigate the effect of Ivermectin (IVM) on the reproductive hormones and hemato-biochemical parameters of twenty apparently healthy ewes weighing 30-40 kg and 2-3 years old. Ewes were randomly divided into two groups (ten for each). The first group was left without treatment (...

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Autores principales:	Ghada H. Abdel-Rahman, Amal H. Ali
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2021
Materias:	ewes hemato-biochemical parameters ivermectin reproductive hormones Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://doaj.org/article/52b18f832937482e93aa99aabf74d042
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spelling	oai:doaj.org-article:52b18f832937482e93aa99aabf74d0422021-12-02T14:28:01ZClinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes10.21608/javs.2021.1643231687-40722090-3308https://doaj.org/article/52b18f832937482e93aa99aabf74d0422021-04-01T00:00:00Zhttps://javs.journals.ekb.eg/article_164323.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308This study aimed to investigate the effect of Ivermectin (IVM) on the reproductive hormones and hemato-biochemical parameters of twenty apparently healthy ewes weighing 30-40 kg and 2-3 years old. Ewes were randomly divided into two groups (ten for each). The first group was left without treatment (control group), and the second was treated with the recommended therapeutic dose of IVM (0.2 mg/kg, S/C) one day after parturition (treated group). The study continued for three months. Blood samples were collected from the two groups at the 1st, 30th, 60th, and 90th days after IVM treatment. The current study revealed that IVM injection delayed estrous for up to 3 months (absence of estrous signs and no ovarian structures were observed by sonar examination). There was a significant decrease in hemoglobin concentration (Hb), red blood cells (RBCs) count, and packed cell volume (PCV), with a significant increase in total leukocytic count (TLC) at 30th and 60th days post-treatment (p.t.). In addition to a significant decreased at (P<0.05) in the activity of glutathione peroxidase (GSH) and concentrations of total antioxidants (TAC), copper (Cu), phosphorus (P), estradiol, triiodothyronine(T3), and tetraiodothyronine (T4) for up to 3 months. In contrast, a significant increase in concentrations of calcium (Ca), progesterone and cortisol, and activity of malondialdehyde (MDA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) enzymes were recorded at 30th and 60th days p.t. It has been concluded that IVM delayed estrous in ewes for three months via disturbing the female reproductive hormones and the hemato-biochemical parameters. Therefore, it is recommended that IVM not be injected at least three months before the reproductive season. Ghada H. Abdel-RahmanAmal H. AliEgyptian Society for Animal Managementarticleeweshemato-biochemical parametersivermectinreproductive hormonesZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 6, Iss 2, Pp 53-60 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ewes hemato-biochemical parameters ivermectin reproductive hormones Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	ewes hemato-biochemical parameters ivermectin reproductive hormones Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Ghada H. Abdel-Rahman Amal H. Ali Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes
description	This study aimed to investigate the effect of Ivermectin (IVM) on the reproductive hormones and hemato-biochemical parameters of twenty apparently healthy ewes weighing 30-40 kg and 2-3 years old. Ewes were randomly divided into two groups (ten for each). The first group was left without treatment (control group), and the second was treated with the recommended therapeutic dose of IVM (0.2 mg/kg, S/C) one day after parturition (treated group). The study continued for three months. Blood samples were collected from the two groups at the 1st, 30th, 60th, and 90th days after IVM treatment. The current study revealed that IVM injection delayed estrous for up to 3 months (absence of estrous signs and no ovarian structures were observed by sonar examination). There was a significant decrease in hemoglobin concentration (Hb), red blood cells (RBCs) count, and packed cell volume (PCV), with a significant increase in total leukocytic count (TLC) at 30th and 60th days post-treatment (p.t.). In addition to a significant decreased at (P<0.05) in the activity of glutathione peroxidase (GSH) and concentrations of total antioxidants (TAC), copper (Cu), phosphorus (P), estradiol, triiodothyronine(T3), and tetraiodothyronine (T4) for up to 3 months. In contrast, a significant increase in concentrations of calcium (Ca), progesterone and cortisol, and activity of malondialdehyde (MDA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) enzymes were recorded at 30th and 60th days p.t. It has been concluded that IVM delayed estrous in ewes for three months via disturbing the female reproductive hormones and the hemato-biochemical parameters. Therefore, it is recommended that IVM not be injected at least three months before the reproductive season.
format	article
author	Ghada H. Abdel-Rahman Amal H. Ali
author_facet	Ghada H. Abdel-Rahman Amal H. Ali
author_sort	Ghada H. Abdel-Rahman
title	Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes
title_short	Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes
title_full	Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes
title_fullStr	Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes
title_full_unstemmed	Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes
title_sort	clinicopathological and reproductive studies on the use of ivermectin in ewes
publisher	Egyptian Society for Animal Management
publishDate	2021
url	https://doaj.org/article/52b18f832937482e93aa99aabf74d042
work_keys_str_mv	AT ghadahabdelrahman clinicopathologicalandreproductivestudiesontheuseofivermectininewes AT amalhali clinicopathologicalandreproductivestudiesontheuseofivermectininewes
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Clinicopathological and Reproductive Studies on The Use of Ivermectin in Ewes

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