Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye

Daniel Sarezky, Aaishah R Raquib, Joshua L Dunaief, Benjamin J Kim Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Purpose: Alpha lipoic acid (ALA) is an antioxidant and iron-chelating supplement that has potential b...

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Autores principales:	Sarezky D, Raquib AR, Dunaief JL, Kim BJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	age-related macular degeneration geographic atrophy antioxidant gastrointestinal dietary supplements Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/52b79bdac8334600a478bf3e0fb44ba2
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spelling	oai:doaj.org-article:52b79bdac8334600a478bf3e0fb44ba22021-12-02T06:10:56ZTolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye1177-5483https://doaj.org/article/52b79bdac8334600a478bf3e0fb44ba22016-09-01T00:00:00Zhttps://www.dovepress.com/tolerability-in-the-elderly-population-of-high-dose-alpha-lipoic-acid--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Daniel Sarezky, Aaishah R Raquib, Joshua L Dunaief, Benjamin J Kim Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Purpose: Alpha lipoic acid (ALA) is an antioxidant and iron-chelating supplement that has potential benefits for geographic atrophy in dry age-related macular degeneration as well as other eye diseases. The purpose of this study was to determine the tolerability of ALA in the elderly population. Patients and methods: Fifteen subjects, age ≥65 years, took sequential ALA doses of 600, 800, and 1,200 mg. Each dose was taken once daily with a meal for 5 days. After each dose was taken by the subjects for 5 days, the subjects were contacted by phone, a review of systems was performed, and they were asked if they thought they could tolerate taking that dose of ALA for an extended period of time. Results: The 600 mg dose was well tolerated. At the 800 mg dose, one subject had an intolerable flushing sensation. At the 1,200 mg dose, two subjects had intolerable upper gastrointestinal side effects and one subject had an intolerable flushing sensation. Subjects taking gastrointestinal prophylaxis medications had no upper gastrointestinal side effects. Conclusion: High-dose ALA is not completely tolerated by the elderly. These preliminary data suggest that gastrointestinal prophylaxis may improve tolerability. (ClinicalTrials.gov, NCT02613572). Keywords: age-related macular degeneration, geographic atrophy, antioxidant, gastrointestinal, dietary supplements, lipoic acidSarezky DRaquib ARDunaief JLKim BJDove Medical Pressarticleage-related macular degenerationgeographic atrophyantioxidantgastrointestinaldietary supplementsOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1899-1903 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	age-related macular degeneration geographic atrophy antioxidant gastrointestinal dietary supplements Ophthalmology RE1-994
spellingShingle	age-related macular degeneration geographic atrophy antioxidant gastrointestinal dietary supplements Ophthalmology RE1-994 Sarezky D Raquib AR Dunaief JL Kim BJ Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
description	Daniel Sarezky, Aaishah R Raquib, Joshua L Dunaief, Benjamin J Kim Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Purpose: Alpha lipoic acid (ALA) is an antioxidant and iron-chelating supplement that has potential benefits for geographic atrophy in dry age-related macular degeneration as well as other eye diseases. The purpose of this study was to determine the tolerability of ALA in the elderly population. Patients and methods: Fifteen subjects, age ≥65 years, took sequential ALA doses of 600, 800, and 1,200 mg. Each dose was taken once daily with a meal for 5 days. After each dose was taken by the subjects for 5 days, the subjects were contacted by phone, a review of systems was performed, and they were asked if they thought they could tolerate taking that dose of ALA for an extended period of time. Results: The 600 mg dose was well tolerated. At the 800 mg dose, one subject had an intolerable flushing sensation. At the 1,200 mg dose, two subjects had intolerable upper gastrointestinal side effects and one subject had an intolerable flushing sensation. Subjects taking gastrointestinal prophylaxis medications had no upper gastrointestinal side effects. Conclusion: High-dose ALA is not completely tolerated by the elderly. These preliminary data suggest that gastrointestinal prophylaxis may improve tolerability. (ClinicalTrials.gov, NCT02613572). Keywords: age-related macular degeneration, geographic atrophy, antioxidant, gastrointestinal, dietary supplements, lipoic acid
format	article
author	Sarezky D Raquib AR Dunaief JL Kim BJ
author_facet	Sarezky D Raquib AR Dunaief JL Kim BJ
author_sort	Sarezky D
title	Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
title_short	Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
title_full	Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
title_fullStr	Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
title_full_unstemmed	Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
title_sort	tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/52b79bdac8334600a478bf3e0fb44ba2
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Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye

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