Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD

Background: Cardiovascular-related mortality is a major concern in NAFLD. Advanced fibrosis was known to be associated with cardiovascular diseases. NAFLD Fibrosis Score (NFS) is used to identify the development of liver fibrosis in NAFLD patients. Left ventricular mass index (LVMI) is a sign of sub...

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Autores principales:	Tri Ferry Rachmatullah, Cecilia Oktaria Permatadewi, Hesti Triwahyu Hutami, Charles Limantoro, Hery Djagat Purnomo, MD, PhD
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2021
Materias:	nafld nfs lvmi nfs with lvmi nfs with lvmi in nafld Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/52bb3dae9a4f42d5b57299c50cf45ce8
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spelling	oai:doaj.org-article:52bb3dae9a4f42d5b57299c50cf45ce82021-11-05T16:47:51ZCorrelation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD2503-217810.14710/jbtr.v7i2.11624https://doaj.org/article/52bb3dae9a4f42d5b57299c50cf45ce82021-08-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/11624https://doaj.org/toc/2503-2178Background: Cardiovascular-related mortality is a major concern in NAFLD. Advanced fibrosis was known to be associated with cardiovascular diseases. NAFLD Fibrosis Score (NFS) is used to identify the development of liver fibrosis in NAFLD patients. Left ventricular mass index (LVMI) is a sign of subclinical cardiovascular complications in NAFLD. The correlation between NAFLD fibrosis score with LVMI in NAFLD patients is not fully established. Objective: To analyze the correlation between NAFLD fibrosis score with LVMI in NAFLD patients. Methods: A cross-sectional study of NAFLD patients in Kariadi Hospital Indonesia. NFS was done using a formula based on clinical and biochemical parameters. LVMI was measured with echocardiography. Pearson’s, Mann-Whitney, and logistic regression were used for analysis. Results: A total of 64 patients with primary NAFLD were enrolled, 54.7% males and 45.3% females. Mean age was 52,8 ± 10,5 years (30-77 years). Based on NFS criteria, high probability group was the highest (50%), followed by intermediate probability group (34,4%) and low probability group (15,6%). Highest increase in LVMI was obtained in the high probability group (93,8%), followed by intermediate probability (59,1%), and low probability group (10%) respectively. There was significant correlation between NFS and LVMI (P 0,002). Logistic regression showed that NFS has a more significant correlation with LVMI compared to gender (P=0,002). Conclusion: NFS is a non‐invasive liver fibrosis scores which independently corelated with Left ventricular mass index (LVMI), a marker of cardiovascular abnormality.Tri Ferry RachmatullahCecilia Oktaria PermatadewiHesti Triwahyu HutamiCharles LimantoroHery Djagat Purnomo, MD, PhDDiponegoro Universityarticlenafldnfslvminfs with lvminfs with lvmi in nafldMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 7, Iss 2, Pp 79-85 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nafld nfs lvmi nfs with lvmi nfs with lvmi in nafld Medicine (General) R5-920
spellingShingle	nafld nfs lvmi nfs with lvmi nfs with lvmi in nafld Medicine (General) R5-920 Tri Ferry Rachmatullah Cecilia Oktaria Permatadewi Hesti Triwahyu Hutami Charles Limantoro Hery Djagat Purnomo, MD, PhD Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD
description	Background: Cardiovascular-related mortality is a major concern in NAFLD. Advanced fibrosis was known to be associated with cardiovascular diseases. NAFLD Fibrosis Score (NFS) is used to identify the development of liver fibrosis in NAFLD patients. Left ventricular mass index (LVMI) is a sign of subclinical cardiovascular complications in NAFLD. The correlation between NAFLD fibrosis score with LVMI in NAFLD patients is not fully established. Objective: To analyze the correlation between NAFLD fibrosis score with LVMI in NAFLD patients. Methods: A cross-sectional study of NAFLD patients in Kariadi Hospital Indonesia. NFS was done using a formula based on clinical and biochemical parameters. LVMI was measured with echocardiography. Pearson’s, Mann-Whitney, and logistic regression were used for analysis. Results: A total of 64 patients with primary NAFLD were enrolled, 54.7% males and 45.3% females. Mean age was 52,8 ± 10,5 years (30-77 years). Based on NFS criteria, high probability group was the highest (50%), followed by intermediate probability group (34,4%) and low probability group (15,6%). Highest increase in LVMI was obtained in the high probability group (93,8%), followed by intermediate probability (59,1%), and low probability group (10%) respectively. There was significant correlation between NFS and LVMI (P 0,002). Logistic regression showed that NFS has a more significant correlation with LVMI compared to gender (P=0,002). Conclusion: NFS is a non‐invasive liver fibrosis scores which independently corelated with Left ventricular mass index (LVMI), a marker of cardiovascular abnormality.
format	article
author	Tri Ferry Rachmatullah Cecilia Oktaria Permatadewi Hesti Triwahyu Hutami Charles Limantoro Hery Djagat Purnomo, MD, PhD
author_facet	Tri Ferry Rachmatullah Cecilia Oktaria Permatadewi Hesti Triwahyu Hutami Charles Limantoro Hery Djagat Purnomo, MD, PhD
author_sort	Tri Ferry Rachmatullah
title	Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD
title_short	Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD
title_full	Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD
title_fullStr	Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD
title_full_unstemmed	Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD
title_sort	correlation between non-alcoholic fatty liver disease (nafld) fibrosis score (nfs) with left ventricular mass index (lvmi) in patients with nafld
publisher	Diponegoro University
publishDate	2021
url	https://doaj.org/article/52bb3dae9a4f42d5b57299c50cf45ce8
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Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD

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