A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection

Abstract Congenital Zika Syndrome (CZS) is characterized by changes in cranial morphology associated with heterogeneous neurological manifestations and cognitive and behavioral impairments. In this syndrome, longitudinal neuroimaging could help clinicians to predict developmental trajectories of chi...

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Autores principales:	João Ricardo Sato, Claudinei Eduardo Biazoli Junior, Elidianne Layanne Medeiros de Araújo, Júlia de Souza Rodrigues, Suellen Marinho Andrade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/52bb564d6645446f9d78675f2683f416
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spelling	oai:doaj.org-article:52bb564d6645446f9d78675f2683f4162021-12-02T18:51:28ZA guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection10.1038/s41598-021-97450-w2045-2322https://doaj.org/article/52bb564d6645446f9d78675f2683f4162021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97450-whttps://doaj.org/toc/2045-2322Abstract Congenital Zika Syndrome (CZS) is characterized by changes in cranial morphology associated with heterogeneous neurological manifestations and cognitive and behavioral impairments. In this syndrome, longitudinal neuroimaging could help clinicians to predict developmental trajectories of children and tailor treatment plans accordingly. However, regularly acquiring magnetic resonance imaging (MRI) has several shortcomings besides cost, particularly those associated with childrens' clinical presentation as sensitivity to environmental stimuli. The indirect monitoring of local neural activity by non-invasive functional near-infrared spectroscopy (fNIRS) technique can be a useful alternative for longitudinally accessing the brain function in children with CZS. In order to provide a common framework for advancing longitudinal neuroimaging assessment, we propose a principled guideline for fNIRS acquisition and analyses in children with neurodevelopmental disorders. Based on our experience on collecting fNIRS data in children with CZS we emphasize the methodological challenges, such as clinical characteristics of the sample, desensitization, movement artifacts and environment control, as well as suggestions for tackling such challenges. Finally, metrics based on fNIRS can be associated with established clinical metrics, thereby opening possibilities for exploring this tool as a long-term predictor when assessing the effectiveness of treatments aimed at children with severe neurodevelopmental disorders.João Ricardo SatoClaudinei Eduardo Biazoli JuniorElidianne Layanne Medeiros de AraújoJúlia de Souza RodriguesSuellen Marinho AndradeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q João Ricardo Sato Claudinei Eduardo Biazoli Junior Elidianne Layanne Medeiros de Araújo Júlia de Souza Rodrigues Suellen Marinho Andrade A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection
description	Abstract Congenital Zika Syndrome (CZS) is characterized by changes in cranial morphology associated with heterogeneous neurological manifestations and cognitive and behavioral impairments. In this syndrome, longitudinal neuroimaging could help clinicians to predict developmental trajectories of children and tailor treatment plans accordingly. However, regularly acquiring magnetic resonance imaging (MRI) has several shortcomings besides cost, particularly those associated with childrens' clinical presentation as sensitivity to environmental stimuli. The indirect monitoring of local neural activity by non-invasive functional near-infrared spectroscopy (fNIRS) technique can be a useful alternative for longitudinally accessing the brain function in children with CZS. In order to provide a common framework for advancing longitudinal neuroimaging assessment, we propose a principled guideline for fNIRS acquisition and analyses in children with neurodevelopmental disorders. Based on our experience on collecting fNIRS data in children with CZS we emphasize the methodological challenges, such as clinical characteristics of the sample, desensitization, movement artifacts and environment control, as well as suggestions for tackling such challenges. Finally, metrics based on fNIRS can be associated with established clinical metrics, thereby opening possibilities for exploring this tool as a long-term predictor when assessing the effectiveness of treatments aimed at children with severe neurodevelopmental disorders.
format	article
author	João Ricardo Sato Claudinei Eduardo Biazoli Junior Elidianne Layanne Medeiros de Araújo Júlia de Souza Rodrigues Suellen Marinho Andrade
author_facet	João Ricardo Sato Claudinei Eduardo Biazoli Junior Elidianne Layanne Medeiros de Araújo Júlia de Souza Rodrigues Suellen Marinho Andrade
author_sort	João Ricardo Sato
title	A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection
title_short	A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection
title_full	A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection
title_fullStr	A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection
title_full_unstemmed	A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection
title_sort	guide for the use of fnirs in microcephaly associated to congenital zika virus infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/52bb564d6645446f9d78675f2683f416
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A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection

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