Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine

The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumulate in MTAP-deficient cancer cells but is secreted...

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Autores principales:	Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
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spelling	oai:doaj.org-article:52cd1479712f4a068ae698d7e4c9858e2021-12-02T15:23:09ZHomozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine10.1038/s41467-021-24240-32041-1723https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24240-3https://doaj.org/toc/2041-1723The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumulate in MTAP-deficient cancer cells but is secreted and metabolized by MTAP-intact cells in the tumour microenvironment.Yasaman BarekatainJeffrey J. AckroydVictoria C. YanSunada KhadkaLin WangKo-Chien ChenAnton H. PoralTheresa TranDimitra K. GeorgiouKenisha ArthurYu-Hsi LinNikunj SataniElliot S. BallatoEliot I. BehrAna C. deCarvalhoRoel G. W. VerhaakJohn de GrootJason T. HuseJohn M. AsaraRaghu KalluriFlorian L. MullerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yasaman Barekatain Jeffrey J. Ackroyd Victoria C. Yan Sunada Khadka Lin Wang Ko-Chien Chen Anton H. Poral Theresa Tran Dimitra K. Georgiou Kenisha Arthur Yu-Hsi Lin Nikunj Satani Elliot S. Ballato Eliot I. Behr Ana C. deCarvalho Roel G. W. Verhaak John de Groot Jason T. Huse John M. Asara Raghu Kalluri Florian L. Muller Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
description	The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumulate in MTAP-deficient cancer cells but is secreted and metabolized by MTAP-intact cells in the tumour microenvironment.
format	article
author	Yasaman Barekatain Jeffrey J. Ackroyd Victoria C. Yan Sunada Khadka Lin Wang Ko-Chien Chen Anton H. Poral Theresa Tran Dimitra K. Georgiou Kenisha Arthur Yu-Hsi Lin Nikunj Satani Elliot S. Ballato Eliot I. Behr Ana C. deCarvalho Roel G. W. Verhaak John de Groot Jason T. Huse John M. Asara Raghu Kalluri Florian L. Muller
author_facet	Yasaman Barekatain Jeffrey J. Ackroyd Victoria C. Yan Sunada Khadka Lin Wang Ko-Chien Chen Anton H. Poral Theresa Tran Dimitra K. Georgiou Kenisha Arthur Yu-Hsi Lin Nikunj Satani Elliot S. Ballato Eliot I. Behr Ana C. deCarvalho Roel G. W. Verhaak John de Groot Jason T. Huse John M. Asara Raghu Kalluri Florian L. Muller
author_sort	Yasaman Barekatain
title	Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
title_short	Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
title_full	Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
title_fullStr	Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
title_full_unstemmed	Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
title_sort	homozygous mtap deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine

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