Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders

Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data g...

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Autores principales:	Annia Galano, Eduardo G. Guzmán-López, Russel J. Reiter
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multifactorial diseases multifunctional drugs antioxidant neuroprotection free radical scavengers metal chelators Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/52d21d493cb84eeb946ad9b6751b5f69
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spelling	oai:doaj.org-article:52d21d493cb84eeb946ad9b6751b5f692021-11-11T17:03:55ZPotentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders10.3390/ijms2221115841422-00671661-6596https://doaj.org/article/52d21d493cb84eeb946ad9b6751b5f692021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11584https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data gathered to date regarding the multiple health benefits of melatonin and related compounds. This review also highlights some of the most recent directions in the discovery of multifunctional pharmaceuticals intended to act as one-molecule multiple-target drugs with potential use in multifactorial diseases, including neurodegenerative disorders. Herein, we discuss the beneficial activities of melatonin derivatives reported to date, in addition to computational strategies to rationally design new derivatives by functionalization of the melatonin molecular framework. It is hoped that this review will promote more investigations on the subject from both experimental and theoretical perspectives.Annia GalanoEduardo G. Guzmán-LópezRussel J. ReiterMDPI AGarticlemultifactorial diseasesmultifunctional drugsantioxidantneuroprotectionfree radical scavengersmetal chelatorsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11584, p 11584 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multifactorial diseases multifunctional drugs antioxidant neuroprotection free radical scavengers metal chelators Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	multifactorial diseases multifunctional drugs antioxidant neuroprotection free radical scavengers metal chelators Biology (General) QH301-705.5 Chemistry QD1-999 Annia Galano Eduardo G. Guzmán-López Russel J. Reiter Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders
description	Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data gathered to date regarding the multiple health benefits of melatonin and related compounds. This review also highlights some of the most recent directions in the discovery of multifunctional pharmaceuticals intended to act as one-molecule multiple-target drugs with potential use in multifactorial diseases, including neurodegenerative disorders. Herein, we discuss the beneficial activities of melatonin derivatives reported to date, in addition to computational strategies to rationally design new derivatives by functionalization of the melatonin molecular framework. It is hoped that this review will promote more investigations on the subject from both experimental and theoretical perspectives.
format	article
author	Annia Galano Eduardo G. Guzmán-López Russel J. Reiter
author_facet	Annia Galano Eduardo G. Guzmán-López Russel J. Reiter
author_sort	Annia Galano
title	Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders
title_short	Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders
title_full	Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders
title_fullStr	Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders
title_full_unstemmed	Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders
title_sort	potentiating the benefits of melatonin through chemical functionalization: possible impact on multifactorial neurodegenerative disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/52d21d493cb84eeb946ad9b6751b5f69
work_keys_str_mv	AT anniagalano potentiatingthebenefitsofmelatoninthroughchemicalfunctionalizationpossibleimpactonmultifactorialneurodegenerativedisorders AT eduardogguzmanlopez potentiatingthebenefitsofmelatoninthroughchemicalfunctionalizationpossibleimpactonmultifactorialneurodegenerativedisorders AT russeljreiter potentiatingthebenefitsofmelatoninthroughchemicalfunctionalizationpossibleimpactonmultifactorialneurodegenerativedisorders
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Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders

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