Advancing diagnostics of chronic paradontitis in children

Chronic periodontitis in children and adolescents holds a lead place in morbidity pattern of dental pathology. Development of chronic periodontitis is accompanied by emergence of various complications in the maxillofacial region, leading to bite disturbance being of high relevance for pediatric pati...

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Autores principales:	N. M. Agarkov, A. S. Makaryan, I. S. Gontareva
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	diagnostics of chronic periodontitis systemic immunity discriminative method children Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/52d2a970d630443a982994c2cded5f34
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spelling	oai:doaj.org-article:52d2a970d630443a982994c2cded5f342021-11-22T07:09:54ZAdvancing diagnostics of chronic paradontitis in children2220-76192313-739810.15789/2220-7619-ADO-1186https://doaj.org/article/52d2a970d630443a982994c2cded5f342020-08-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1186https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Chronic periodontitis in children and adolescents holds a lead place in morbidity pattern of dental pathology. Development of chronic periodontitis is accompanied by emergence of various complications in the maxillofacial region, leading to bite disturbance being of high relevance for pediatric patients. These and other complications are related to immune system immaturity in children and adolescents as well as virulence of microorganisms. However, the immunological changes developing in children with chronic periodontitis remain poorly studied. The aim of the work was to improve diagnostics of chronic periodontitis in children and adolescents based on informative parameters of systemic immunity and discriminative models taking into account such changes. We examined systemic immunity in 127 children and adolescents with chronic periodontitis, aged 12 to 16 years, by using flow cytometry and enzyme immunoassay. In control group, age-matched 108 patients lacking overt somatic and dental pathology were enrolled. Generation of mathematical models was carried out by using a discriminative approach, whereas informativeness was assessed in accordance with generally accepted formula. Relative and absolute count of peripheral blood CD13+ cells exert the peak informativeness holding the first and second ranking places with marked dominance of informativeness value for assessing relative amount of CD13+ cells are among immunological parameters in children with chronic periodontitis. High informativeness value evidencing about pronounced intensity of developed pathological changes and diagnostic significance for chronic periodontitis in children is intrinsic to the relative percentage of peripheral blood CD8+ cells being slightly lower than that one in absolute count of CD13+ cells. On the other hand, humoral immune-parameters were of lowest informative value among all analyzed immunological parameters in patients with chronic periodontitis serum referring to all antibody classes. Generated discriminative models for the most valuable immunological parameters ensure adequate medical diagnostics for chronic periodontitis in childhood. Diagnostic sensitivity for created mathematical models was high and reached 0.94, whereas diagnostic specificity — 0.92. Immunological examination of patients improves diagnostics of chronic periodontitis. It was found that patients with chronic periodontitis had lowered immune status peaking in decreased absolute and relative count of peripheral blood CD3+ lymphocytes. Finally, parameters of humoral immunity in children with chronic periodontitis were also reduced.N. M. AgarkovA. S. MakaryanI. S. GontarevaSankt-Peterburg : NIIÈM imeni Pasteraarticlediagnostics of chronic periodontitissystemic immunitydiscriminative methodchildrenInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 3, Pp 558-564 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	diagnostics of chronic periodontitis systemic immunity discriminative method children Infectious and parasitic diseases RC109-216
spellingShingle	diagnostics of chronic periodontitis systemic immunity discriminative method children Infectious and parasitic diseases RC109-216 N. M. Agarkov A. S. Makaryan I. S. Gontareva Advancing diagnostics of chronic paradontitis in children
description	Chronic periodontitis in children and adolescents holds a lead place in morbidity pattern of dental pathology. Development of chronic periodontitis is accompanied by emergence of various complications in the maxillofacial region, leading to bite disturbance being of high relevance for pediatric patients. These and other complications are related to immune system immaturity in children and adolescents as well as virulence of microorganisms. However, the immunological changes developing in children with chronic periodontitis remain poorly studied. The aim of the work was to improve diagnostics of chronic periodontitis in children and adolescents based on informative parameters of systemic immunity and discriminative models taking into account such changes. We examined systemic immunity in 127 children and adolescents with chronic periodontitis, aged 12 to 16 years, by using flow cytometry and enzyme immunoassay. In control group, age-matched 108 patients lacking overt somatic and dental pathology were enrolled. Generation of mathematical models was carried out by using a discriminative approach, whereas informativeness was assessed in accordance with generally accepted formula. Relative and absolute count of peripheral blood CD13+ cells exert the peak informativeness holding the first and second ranking places with marked dominance of informativeness value for assessing relative amount of CD13+ cells are among immunological parameters in children with chronic periodontitis. High informativeness value evidencing about pronounced intensity of developed pathological changes and diagnostic significance for chronic periodontitis in children is intrinsic to the relative percentage of peripheral blood CD8+ cells being slightly lower than that one in absolute count of CD13+ cells. On the other hand, humoral immune-parameters were of lowest informative value among all analyzed immunological parameters in patients with chronic periodontitis serum referring to all antibody classes. Generated discriminative models for the most valuable immunological parameters ensure adequate medical diagnostics for chronic periodontitis in childhood. Diagnostic sensitivity for created mathematical models was high and reached 0.94, whereas diagnostic specificity — 0.92. Immunological examination of patients improves diagnostics of chronic periodontitis. It was found that patients with chronic periodontitis had lowered immune status peaking in decreased absolute and relative count of peripheral blood CD3+ lymphocytes. Finally, parameters of humoral immunity in children with chronic periodontitis were also reduced.
format	article
author	N. M. Agarkov A. S. Makaryan I. S. Gontareva
author_facet	N. M. Agarkov A. S. Makaryan I. S. Gontareva
author_sort	N. M. Agarkov
title	Advancing diagnostics of chronic paradontitis in children
title_short	Advancing diagnostics of chronic paradontitis in children
title_full	Advancing diagnostics of chronic paradontitis in children
title_fullStr	Advancing diagnostics of chronic paradontitis in children
title_full_unstemmed	Advancing diagnostics of chronic paradontitis in children
title_sort	advancing diagnostics of chronic paradontitis in children
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/52d2a970d630443a982994c2cded5f34
work_keys_str_mv	AT nmagarkov advancingdiagnosticsofchronicparadontitisinchildren AT asmakaryan advancingdiagnosticsofchronicparadontitisinchildren AT isgontareva advancingdiagnosticsofchronicparadontitisinchildren
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Advancing diagnostics of chronic paradontitis in children

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