Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific...

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Autores principales:	Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre-Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Olufunmilayo Olopade, Zhaohui S. Qin, Charles Rotimi, Nicolas Vince, Harold Watson, Rainford J. Wilks, James G. Wilson, Steven Salzberg, Carole Ober, Esteban G. Burchard, L. Keoki Williams, Terri H. Beaty, Margaret A. Taub, Ingo Ruczinski, Rasika A. Mathias, Kathleen C. Barnes, CAAPA
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52d5362512b747ddbffccc263d738739
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spelling	oai:doaj.org-article:52d5362512b747ddbffccc263d7387392021-12-02T15:36:18ZAssociation study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations10.1038/s41467-019-08469-72041-1723https://doaj.org/article/52d5362512b747ddbffccc263d7387392019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08469-7https://doaj.org/toc/2041-1723The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.Michelle DayaNicholas RafaelsTonya M. BrunettiSameer ChavanAlbert M. LevinAniket ShettyChristopher R. GignouxMeher Preethi BoorgulaGenevieve WojcikMonica CampbellCandelaria VergaraDara G. TorgersonVictor E. OrtegaAyo DoumateyHenry Richard JohnstonNathalie AcevedoMaria Ilma AraujoPedro C. AvilaGillian BelbinEugene BleeckerCarlos BustamanteLuis CaraballoAlvaro CruzGeorgia M. DunstonCeleste EngMezbah U. FaruqueTrevor S. FergusonCamila FigueiredoJean G. FordWeiniu GanPierre-Antoine GourraudNadia N. HanselRyan D. HernandezEdwin Francisco Herrera-PazSilvia JiménezEimear E. KennyJennifer Knight-MaddenRajesh KumarLeslie A. LangeEthan M. LangeAntoine LizeePissamai MaulTrevor MaulAlvaro MayorgaDeborah MeyersDan L. NicolaeTimothy D. O’ConnorRicardo Riccio OliveiraChristopher O. OlopadeOlufunmilayo OlopadeZhaohui S. QinCharles RotimiNicolas VinceHarold WatsonRainford J. WilksJames G. WilsonSteven SalzbergCarole OberEsteban G. BurchardL. Keoki WilliamsTerri H. BeatyMargaret A. TaubIngo RuczinskiRasika A. MathiasKathleen C. BarnesCAAPANature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michelle Daya Nicholas Rafaels Tonya M. Brunetti Sameer Chavan Albert M. Levin Aniket Shetty Christopher R. Gignoux Meher Preethi Boorgula Genevieve Wojcik Monica Campbell Candelaria Vergara Dara G. Torgerson Victor E. Ortega Ayo Doumatey Henry Richard Johnston Nathalie Acevedo Maria Ilma Araujo Pedro C. Avila Gillian Belbin Eugene Bleecker Carlos Bustamante Luis Caraballo Alvaro Cruz Georgia M. Dunston Celeste Eng Mezbah U. Faruque Trevor S. Ferguson Camila Figueiredo Jean G. Ford Weiniu Gan Pierre-Antoine Gourraud Nadia N. Hansel Ryan D. Hernandez Edwin Francisco Herrera-Paz Silvia Jiménez Eimear E. Kenny Jennifer Knight-Madden Rajesh Kumar Leslie A. Lange Ethan M. Lange Antoine Lizee Pissamai Maul Trevor Maul Alvaro Mayorga Deborah Meyers Dan L. Nicolae Timothy D. O’Connor Ricardo Riccio Oliveira Christopher O. Olopade Olufunmilayo Olopade Zhaohui S. Qin Charles Rotimi Nicolas Vince Harold Watson Rainford J. Wilks James G. Wilson Steven Salzberg Carole Ober Esteban G. Burchard L. Keoki Williams Terri H. Beaty Margaret A. Taub Ingo Ruczinski Rasika A. Mathias Kathleen C. Barnes CAAPA Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
description	The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.
format	article
author	Michelle Daya Nicholas Rafaels Tonya M. Brunetti Sameer Chavan Albert M. Levin Aniket Shetty Christopher R. Gignoux Meher Preethi Boorgula Genevieve Wojcik Monica Campbell Candelaria Vergara Dara G. Torgerson Victor E. Ortega Ayo Doumatey Henry Richard Johnston Nathalie Acevedo Maria Ilma Araujo Pedro C. Avila Gillian Belbin Eugene Bleecker Carlos Bustamante Luis Caraballo Alvaro Cruz Georgia M. Dunston Celeste Eng Mezbah U. Faruque Trevor S. Ferguson Camila Figueiredo Jean G. Ford Weiniu Gan Pierre-Antoine Gourraud Nadia N. Hansel Ryan D. Hernandez Edwin Francisco Herrera-Paz Silvia Jiménez Eimear E. Kenny Jennifer Knight-Madden Rajesh Kumar Leslie A. Lange Ethan M. Lange Antoine Lizee Pissamai Maul Trevor Maul Alvaro Mayorga Deborah Meyers Dan L. Nicolae Timothy D. O’Connor Ricardo Riccio Oliveira Christopher O. Olopade Olufunmilayo Olopade Zhaohui S. Qin Charles Rotimi Nicolas Vince Harold Watson Rainford J. Wilks James G. Wilson Steven Salzberg Carole Ober Esteban G. Burchard L. Keoki Williams Terri H. Beaty Margaret A. Taub Ingo Ruczinski Rasika A. Mathias Kathleen C. Barnes CAAPA
author_facet	Michelle Daya Nicholas Rafaels Tonya M. Brunetti Sameer Chavan Albert M. Levin Aniket Shetty Christopher R. Gignoux Meher Preethi Boorgula Genevieve Wojcik Monica Campbell Candelaria Vergara Dara G. Torgerson Victor E. Ortega Ayo Doumatey Henry Richard Johnston Nathalie Acevedo Maria Ilma Araujo Pedro C. Avila Gillian Belbin Eugene Bleecker Carlos Bustamante Luis Caraballo Alvaro Cruz Georgia M. Dunston Celeste Eng Mezbah U. Faruque Trevor S. Ferguson Camila Figueiredo Jean G. Ford Weiniu Gan Pierre-Antoine Gourraud Nadia N. Hansel Ryan D. Hernandez Edwin Francisco Herrera-Paz Silvia Jiménez Eimear E. Kenny Jennifer Knight-Madden Rajesh Kumar Leslie A. Lange Ethan M. Lange Antoine Lizee Pissamai Maul Trevor Maul Alvaro Mayorga Deborah Meyers Dan L. Nicolae Timothy D. O’Connor Ricardo Riccio Oliveira Christopher O. Olopade Olufunmilayo Olopade Zhaohui S. Qin Charles Rotimi Nicolas Vince Harold Watson Rainford J. Wilks James G. Wilson Steven Salzberg Carole Ober Esteban G. Burchard L. Keoki Williams Terri H. Beaty Margaret A. Taub Ingo Ruczinski Rasika A. Mathias Kathleen C. Barnes CAAPA
author_sort	Michelle Daya
title	Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
title_short	Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
title_full	Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
title_fullStr	Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
title_full_unstemmed	Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
title_sort	association study in african-admixed populations across the americas recapitulates asthma risk loci in non-african populations
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/52d5362512b747ddbffccc263d738739
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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

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