Five-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice

Andrew Moshfeghi,1 Vincent Garmo,2 Daniel Sheinson,2 Avanti Ghanekar,2 Ibrahim Abbass2 1USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 2Genentech, Inc., South San Francisco, CA, USACorrespondence: Andrew Moshfeg...

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Autores principales: Moshfeghi A, Garmo V, Sheinson D, Ghanekar A, Abbass I
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Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:52d5e5e6202f4c0a9e6704b5df17d47e2021-12-02T12:56:01ZFive-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice1177-5483https://doaj.org/article/52d5e5e6202f4c0a9e6704b5df17d47e2020-10-01T00:00:00Zhttps://www.dovepress.com/five-year-patterns-of-diabetic-retinopathy-progression-in-us-clinical--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Andrew Moshfeghi,1 Vincent Garmo,2 Daniel Sheinson,2 Avanti Ghanekar,2 Ibrahim Abbass2 1USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 2Genentech, Inc., South San Francisco, CA, USACorrespondence: Andrew MoshfeghiUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 4700, Los Angeles, CA 90033, USATel +1 323 442 6335Fax +1 323 442 6410Email moshfega@med.usc.eduPurpose: To characterize the natural course of diabetic retinopathy (DR) in contemporary clinical practice.Patients and Methods: This was a retrospective analysis of US claims data collected between January 1, 2006, and April 30, 2017. Patients aged ≥ 18 years with continuous medical and prescription insurance coverage for 18 months before DR diagnosis (index date) and for a follow-up period of 5 years were included (N=14,490). The time and risk of progressing to severe nonproliferative DR (NPDR) or proliferative DR (PDR) and of developing diabetic macular edema (DME) were evaluated over 5 years in patients stratified by DR severity at initial diagnosis.Results: The estimated probability of progressing to severe NPDR or PDR within 5 years of diagnosis was 17.6% for patients with moderate NPDR versus 5.8% for mild NPDR. The probability of developing DME within 5 years was 62.6%, 44.6%, and 28.4% for patients diagnosed with severe NPDR, moderate NPDR, and PDR, respectively, versus 15.6% for mild NPDR. Among those observed to progress, median time to severe NPDR or PDR was approximately 2.0 years in patients with moderate NPDR, whereas median time to DME was approximately 0.5 years in patients with severe NPDR, 1.3 years in moderate NPDR, and 1.6 years in PDR. Relative to mild NPDR, adjusted hazard ratios (95% confidence interval) for progression to severe NPDR or PDR within 5 years were 3.12 (2.61– 3.72) in patients with moderate NPDR, and for incident DME were 5.92 (5.13– 6.82), 3.54 (3.22– 3.91), and 1.96 (1.80– 2.14) in patients with severe NPDR, moderate NPDR, and PDR, respectively.Conclusion: The risk of DR progression and DME over 5 years was highest among patients diagnosed with moderate and severe NPDR, respectively. Our findings reinforce the importance of close monitoring for these patients to avoid unobserved disease progression toward PDR and/or DME.Keywords: diabetic macular edema, diabetic retinopathy, disease progression, real-world evidenceMoshfeghi AGarmo VSheinson DGhanekar AAbbass IDove Medical Pressarticlediabetic macular edemadiabetic retinopathydisease progressionreal-world evidenceOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3651-3659 (2020)
institution DOAJ
collection DOAJ
language EN
topic diabetic macular edema
diabetic retinopathy
disease progression
real-world evidence
Ophthalmology
RE1-994
spellingShingle diabetic macular edema
diabetic retinopathy
disease progression
real-world evidence
Ophthalmology
RE1-994
Moshfeghi A
Garmo V
Sheinson D
Ghanekar A
Abbass I
Five-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice
description Andrew Moshfeghi,1 Vincent Garmo,2 Daniel Sheinson,2 Avanti Ghanekar,2 Ibrahim Abbass2 1USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 2Genentech, Inc., South San Francisco, CA, USACorrespondence: Andrew MoshfeghiUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Suite 4700, Los Angeles, CA 90033, USATel +1 323 442 6335Fax +1 323 442 6410Email moshfega@med.usc.eduPurpose: To characterize the natural course of diabetic retinopathy (DR) in contemporary clinical practice.Patients and Methods: This was a retrospective analysis of US claims data collected between January 1, 2006, and April 30, 2017. Patients aged ≥ 18 years with continuous medical and prescription insurance coverage for 18 months before DR diagnosis (index date) and for a follow-up period of 5 years were included (N=14,490). The time and risk of progressing to severe nonproliferative DR (NPDR) or proliferative DR (PDR) and of developing diabetic macular edema (DME) were evaluated over 5 years in patients stratified by DR severity at initial diagnosis.Results: The estimated probability of progressing to severe NPDR or PDR within 5 years of diagnosis was 17.6% for patients with moderate NPDR versus 5.8% for mild NPDR. The probability of developing DME within 5 years was 62.6%, 44.6%, and 28.4% for patients diagnosed with severe NPDR, moderate NPDR, and PDR, respectively, versus 15.6% for mild NPDR. Among those observed to progress, median time to severe NPDR or PDR was approximately 2.0 years in patients with moderate NPDR, whereas median time to DME was approximately 0.5 years in patients with severe NPDR, 1.3 years in moderate NPDR, and 1.6 years in PDR. Relative to mild NPDR, adjusted hazard ratios (95% confidence interval) for progression to severe NPDR or PDR within 5 years were 3.12 (2.61– 3.72) in patients with moderate NPDR, and for incident DME were 5.92 (5.13– 6.82), 3.54 (3.22– 3.91), and 1.96 (1.80– 2.14) in patients with severe NPDR, moderate NPDR, and PDR, respectively.Conclusion: The risk of DR progression and DME over 5 years was highest among patients diagnosed with moderate and severe NPDR, respectively. Our findings reinforce the importance of close monitoring for these patients to avoid unobserved disease progression toward PDR and/or DME.Keywords: diabetic macular edema, diabetic retinopathy, disease progression, real-world evidence
format article
author Moshfeghi A
Garmo V
Sheinson D
Ghanekar A
Abbass I
author_facet Moshfeghi A
Garmo V
Sheinson D
Ghanekar A
Abbass I
author_sort Moshfeghi A
title Five-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice
title_short Five-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice
title_full Five-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice
title_fullStr Five-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice
title_full_unstemmed Five-Year Patterns of Diabetic Retinopathy Progression in US Clinical Practice
title_sort five-year patterns of diabetic retinopathy progression in us clinical practice
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/52d5e5e6202f4c0a9e6704b5df17d47e
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AT ghanekara fiveyearpatternsofdiabeticretinopathyprogressioninusclinicalpractice
AT abbassi fiveyearpatternsofdiabeticretinopathyprogressioninusclinicalpractice
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