Recent Advances in Natural Materials for Corneal Tissue Engineering

Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strate...

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Autores principales:	Julie F. Jameson, Marisa O. Pacheco, Henry H. Nguyen, Edward A. Phelps, Whitney L. Stoppel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	corneal tissue engineering natural biomaterials cornea biomimetic materials Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/52d641fd1ba74f8c84b348c8005410c9
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spelling	oai:doaj.org-article:52d641fd1ba74f8c84b348c8005410c92021-11-25T16:46:26ZRecent Advances in Natural Materials for Corneal Tissue Engineering10.3390/bioengineering81101612306-5354https://doaj.org/article/52d641fd1ba74f8c84b348c8005410c92021-10-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/161https://doaj.org/toc/2306-5354Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strategies aim to address existing complications with human corneal transplants, including graft rejection, infection, and complications resulting from surgical methodologies. The main goals of these research endeavors are to (1) determine ideal mechanical properties, (2) devise methodologies to improve the efficacy of engineered corneal grafts and cell-based therapies, and (3) optimize transplantation of engineered tissue structures in the eye. Thus, recent innovations have sought to address these challenges through both in vitro and in vivo studies. This review covers recent work aimed at evaluating engineered materials, potential therapeutic cells, and the resulting cell-material interactions that lead to optimal corneal graft properties. Furthermore, we discuss promising strategies in corneal tissue engineering techniques and in vivo studies in animal models.Julie F. JamesonMarisa O. PachecoHenry H. NguyenEdward A. PhelpsWhitney L. StoppelMDPI AGarticlecorneal tissue engineeringnatural biomaterialscorneabiomimetic materialsTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 161, p 161 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal tissue engineering natural biomaterials cornea biomimetic materials Technology T Biology (General) QH301-705.5
spellingShingle	corneal tissue engineering natural biomaterials cornea biomimetic materials Technology T Biology (General) QH301-705.5 Julie F. Jameson Marisa O. Pacheco Henry H. Nguyen Edward A. Phelps Whitney L. Stoppel Recent Advances in Natural Materials for Corneal Tissue Engineering
description	Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strategies aim to address existing complications with human corneal transplants, including graft rejection, infection, and complications resulting from surgical methodologies. The main goals of these research endeavors are to (1) determine ideal mechanical properties, (2) devise methodologies to improve the efficacy of engineered corneal grafts and cell-based therapies, and (3) optimize transplantation of engineered tissue structures in the eye. Thus, recent innovations have sought to address these challenges through both in vitro and in vivo studies. This review covers recent work aimed at evaluating engineered materials, potential therapeutic cells, and the resulting cell-material interactions that lead to optimal corneal graft properties. Furthermore, we discuss promising strategies in corneal tissue engineering techniques and in vivo studies in animal models.
format	article
author	Julie F. Jameson Marisa O. Pacheco Henry H. Nguyen Edward A. Phelps Whitney L. Stoppel
author_facet	Julie F. Jameson Marisa O. Pacheco Henry H. Nguyen Edward A. Phelps Whitney L. Stoppel
author_sort	Julie F. Jameson
title	Recent Advances in Natural Materials for Corneal Tissue Engineering
title_short	Recent Advances in Natural Materials for Corneal Tissue Engineering
title_full	Recent Advances in Natural Materials for Corneal Tissue Engineering
title_fullStr	Recent Advances in Natural Materials for Corneal Tissue Engineering
title_full_unstemmed	Recent Advances in Natural Materials for Corneal Tissue Engineering
title_sort	recent advances in natural materials for corneal tissue engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/52d641fd1ba74f8c84b348c8005410c9
work_keys_str_mv	AT juliefjameson recentadvancesinnaturalmaterialsforcornealtissueengineering AT marisaopacheco recentadvancesinnaturalmaterialsforcornealtissueengineering AT henryhnguyen recentadvancesinnaturalmaterialsforcornealtissueengineering AT edwardaphelps recentadvancesinnaturalmaterialsforcornealtissueengineering AT whitneylstoppel recentadvancesinnaturalmaterialsforcornealtissueengineering
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Recent Advances in Natural Materials for Corneal Tissue Engineering

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