Human skin hypoxia modulates cerebrovascular and autonomic functions.

Because the skin is an oxygen sensor in amphibians and mice, we thought to confirm this function also in humans. The human upright posture, however, introduces additional functional demands for the maintenance of oxygen homeostasis in which cerebral blood flow and autonomic nervous system (ANS) func...

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Autores principales:	Olivia Pucci, Clifford Qualls, Anne Battisti-Charbonney, Dahlia Y Balaban, Joe A Fisher, Jim Duffin, Otto Appenzeller
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/52d678700f83449cb2e593bd662039a5
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spelling	oai:doaj.org-article:52d678700f83449cb2e593bd662039a52021-11-18T08:12:47ZHuman skin hypoxia modulates cerebrovascular and autonomic functions.1932-620310.1371/journal.pone.0047116https://doaj.org/article/52d678700f83449cb2e593bd662039a52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23056597/?tool=EBIhttps://doaj.org/toc/1932-6203Because the skin is an oxygen sensor in amphibians and mice, we thought to confirm this function also in humans. The human upright posture, however, introduces additional functional demands for the maintenance of oxygen homeostasis in which cerebral blood flow and autonomic nervous system (ANS) function may also be involved. We examined nine males and three females. While subjects were breathing ambient air, at sea level, we changed gases in a plastic body-bag during two conditions of the experiment such as to induce skin hypoxia (with pure nitrogen) or skin normoxia (with air). The subjects performed a test of hypoxic ventilatory drive during each condition of the experiment. We found no differences in the hypoxic ventilatory drive tests. However, ANS function and cerebral blood flow velocities were modulated by skin hypoxia and the effect was significantly greater on the left than right middle cerebral arteries. We conclude that skin hypoxia modulates ANS function and cerebral blood flow velocities and this might impact life styles and tolerance to ambient hypoxia at altitude. Thus the skin in normal humans, in addition to its numerous other functions, is also an oxygen sensor.Olivia PucciClifford QuallsAnne Battisti-CharbonneyDahlia Y BalabanJoe A FisherJim DuffinOtto AppenzellerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47116 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Olivia Pucci Clifford Qualls Anne Battisti-Charbonney Dahlia Y Balaban Joe A Fisher Jim Duffin Otto Appenzeller Human skin hypoxia modulates cerebrovascular and autonomic functions.
description	Because the skin is an oxygen sensor in amphibians and mice, we thought to confirm this function also in humans. The human upright posture, however, introduces additional functional demands for the maintenance of oxygen homeostasis in which cerebral blood flow and autonomic nervous system (ANS) function may also be involved. We examined nine males and three females. While subjects were breathing ambient air, at sea level, we changed gases in a plastic body-bag during two conditions of the experiment such as to induce skin hypoxia (with pure nitrogen) or skin normoxia (with air). The subjects performed a test of hypoxic ventilatory drive during each condition of the experiment. We found no differences in the hypoxic ventilatory drive tests. However, ANS function and cerebral blood flow velocities were modulated by skin hypoxia and the effect was significantly greater on the left than right middle cerebral arteries. We conclude that skin hypoxia modulates ANS function and cerebral blood flow velocities and this might impact life styles and tolerance to ambient hypoxia at altitude. Thus the skin in normal humans, in addition to its numerous other functions, is also an oxygen sensor.
format	article
author	Olivia Pucci Clifford Qualls Anne Battisti-Charbonney Dahlia Y Balaban Joe A Fisher Jim Duffin Otto Appenzeller
author_facet	Olivia Pucci Clifford Qualls Anne Battisti-Charbonney Dahlia Y Balaban Joe A Fisher Jim Duffin Otto Appenzeller
author_sort	Olivia Pucci
title	Human skin hypoxia modulates cerebrovascular and autonomic functions.
title_short	Human skin hypoxia modulates cerebrovascular and autonomic functions.
title_full	Human skin hypoxia modulates cerebrovascular and autonomic functions.
title_fullStr	Human skin hypoxia modulates cerebrovascular and autonomic functions.
title_full_unstemmed	Human skin hypoxia modulates cerebrovascular and autonomic functions.
title_sort	human skin hypoxia modulates cerebrovascular and autonomic functions.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/52d678700f83449cb2e593bd662039a5
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Human skin hypoxia modulates cerebrovascular and autonomic functions.

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