Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations
Understanding mechanisms that underly the transition from acute to chronic pain, and identifying potential targets for preventing or minimizing this progression, have specific relevance for chronic post-surgical pain (CPSP). While it is clear that multiple psychosocial, family and environmental fact...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | article |
| Lenguaje: | EN FR |
| Publicado: |
Taylor & Francis Group
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/52d8ef58f0af4cbdb2ad5dd0908b35af |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Understanding mechanisms that underly the transition from acute to chronic pain, and identifying potential targets for preventing or minimizing this progression, have specific relevance for chronic post-surgical pain (CPSP). While it is clear that multiple psychosocial, family and environmental factors may influence CPSP, this review will focus on parallels between clinical observations and translational laboratory studies investigating the acute and long-term effects of surgical injury on nociceptive pathways. This includes data related to alterations in sensitivity at different points along nociceptive pathways from the periphery to brain; age- and sex-dependent mechanisms underlying the transition from acute to persistent pain; potential targets for preventive interventions; and the impact of prior surgical injury. Ongoing preclinical studies evaluating age- and sex-dependent mechanisms will also inform comparative efficacy and pre-clinical safety assessments of potential preventive pharmacological interventions aimed at reducing the risk of CPSP. In future clinical studies, more detailed and longitudinal peri-operative phenotyping with patient- and parent-reported chronic pain core outcomes, alongside more specialized evaluations of somatosensory function, modulation and circuitry, may enhance understanding of individual variability in post-surgical pain trajectories and improve recognition and management of CPSP. |
|---|