Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations

Understanding mechanisms that underly the transition from acute to chronic pain, and identifying potential targets for preventing or minimizing this progression, have specific relevance for chronic post-surgical pain (CPSP). While it is clear that multiple psychosocial, family and environmental fact...

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Autor principal:	Suellen M. Walker
Formato:	article
Lenguaje:	EN FR
Publicado:	Taylor & Francis Group 2021
Materias:	pain surgery children nociception developmental neurobiology somatosensory phenotype Medicine (General) R5-920 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/52d8ef58f0af4cbdb2ad5dd0908b35af
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spelling	oai:doaj.org-article:52d8ef58f0af4cbdb2ad5dd0908b35af2021-11-17T14:22:00ZDevelopmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations2474-052710.1080/24740527.2021.1999796https://doaj.org/article/52d8ef58f0af4cbdb2ad5dd0908b35af2021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/24740527.2021.1999796https://doaj.org/toc/2474-0527Understanding mechanisms that underly the transition from acute to chronic pain, and identifying potential targets for preventing or minimizing this progression, have specific relevance for chronic post-surgical pain (CPSP). While it is clear that multiple psychosocial, family and environmental factors may influence CPSP, this review will focus on parallels between clinical observations and translational laboratory studies investigating the acute and long-term effects of surgical injury on nociceptive pathways. This includes data related to alterations in sensitivity at different points along nociceptive pathways from the periphery to brain; age- and sex-dependent mechanisms underlying the transition from acute to persistent pain; potential targets for preventive interventions; and the impact of prior surgical injury. Ongoing preclinical studies evaluating age- and sex-dependent mechanisms will also inform comparative efficacy and pre-clinical safety assessments of potential preventive pharmacological interventions aimed at reducing the risk of CPSP. In future clinical studies, more detailed and longitudinal peri-operative phenotyping with patient- and parent-reported chronic pain core outcomes, alongside more specialized evaluations of somatosensory function, modulation and circuitry, may enhance understanding of individual variability in post-surgical pain trajectories and improve recognition and management of CPSP.Suellen M. WalkerTaylor & Francis Grouparticlepainsurgerychildrennociceptiondevelopmental neurobiologysomatosensory phenotypeMedicine (General)R5-920Therapeutics. PharmacologyRM1-950ENFRCanadian Journal of Pain, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	pain surgery children nociception developmental neurobiology somatosensory phenotype Medicine (General) R5-920 Therapeutics. Pharmacology RM1-950
spellingShingle	pain surgery children nociception developmental neurobiology somatosensory phenotype Medicine (General) R5-920 Therapeutics. Pharmacology RM1-950 Suellen M. Walker Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations
description	Understanding mechanisms that underly the transition from acute to chronic pain, and identifying potential targets for preventing or minimizing this progression, have specific relevance for chronic post-surgical pain (CPSP). While it is clear that multiple psychosocial, family and environmental factors may influence CPSP, this review will focus on parallels between clinical observations and translational laboratory studies investigating the acute and long-term effects of surgical injury on nociceptive pathways. This includes data related to alterations in sensitivity at different points along nociceptive pathways from the periphery to brain; age- and sex-dependent mechanisms underlying the transition from acute to persistent pain; potential targets for preventive interventions; and the impact of prior surgical injury. Ongoing preclinical studies evaluating age- and sex-dependent mechanisms will also inform comparative efficacy and pre-clinical safety assessments of potential preventive pharmacological interventions aimed at reducing the risk of CPSP. In future clinical studies, more detailed and longitudinal peri-operative phenotyping with patient- and parent-reported chronic pain core outcomes, alongside more specialized evaluations of somatosensory function, modulation and circuitry, may enhance understanding of individual variability in post-surgical pain trajectories and improve recognition and management of CPSP.
format	article
author	Suellen M. Walker
author_facet	Suellen M. Walker
author_sort	Suellen M. Walker
title	Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations
title_short	Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations
title_full	Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations
title_fullStr	Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations
title_full_unstemmed	Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations
title_sort	developmental mechanisms of cpsp: clinical observations and translational laboratory evaluations
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/52d8ef58f0af4cbdb2ad5dd0908b35af
work_keys_str_mv	AT suellenmwalker developmentalmechanismsofcpspclinicalobservationsandtranslationallaboratoryevaluations
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Developmental Mechanisms of CPSP: Clinical Observations and Translational Laboratory Evaluations

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