Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane

BACKGROUND AND OBJECTIVE: One of the important aims in anesthetic management during ocular surgery is to provide adequate control of intraocular pressure (IOP) and increasing of this pressure would cause some dramatic complications even though visual loss. The aim of this research was to evaluate th...

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Autores principales:	MR Ghodrati, A Shakeri, N Farnoush, A Shakeri
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	remifentanil isoflurane intraocular pressure cataract placebo hemodynamic Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/52d99fadef4b49a29848c36e641cdb4a
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spelling	oai:doaj.org-article:52d99fadef4b49a29848c36e641cdb4a2021-11-10T09:03:07ZEffect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane1561-41072251-7170https://doaj.org/article/52d99fadef4b49a29848c36e641cdb4a2009-12-01T00:00:00Zhttp://jbums.org/article-1-3356-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: One of the important aims in anesthetic management during ocular surgery is to provide adequate control of intraocular pressure (IOP) and increasing of this pressure would cause some dramatic complications even though visual loss. The aim of this research was to evaluate the effects of adding remifentanil to isoflurane anesthesia on intraocular pressure (IOP) and hemodynamic responses after intubation and during cataract surgery. METHODS: This study was conducted as randomized clinical trial. Forty patients (20 in each group) enrolled and assigned in two group, isoflurane + remifentanil (R), and isoflurane + placebo (P). Anesthesia was induced in both groups with Na-thiopental 5 mg/kg and atracorium 0.5 mg/kg body weight. In group (R), the patients received1 µg/kg as bolus dose of remifentanil and then continuous infusion 0.1 µg/kg/min was started. In placebo group, saline was infused. IOP and mean arterial pressure (MAP) was measured at 8 different times (zero time, after premedication, after induction of anesthesia, immediately 3 and 6 min after intubation, at the end of surgery and 5 min after remifentanil stopping) by a blind surgeon to research. FINDINGS: Primary IOP in group R was 12.7±3.1 mmhg, and in group P was 13.7±3.4 mmHg. After injection of premedication and induction drugs IOP was decreased obviously in two groups. In both groups mean IOP increased after intubation significantly and reach to 12.1±2.8 mmhg and 14.2±3.2 respectively in group R and P that this difference was not significant. Comparison of MAP between two groups only in third measure (after induction of anesthesia) was meaningful (74.6±14.9 in group R and 88.2±14.1 mmhg in group P) (p=0.005).CONCLUSION: This research was shown that adding of remifentanil to isoflurane in cataract anesthesia could prevent from increasing of IOP due to tracheal intubation.MR Ghodrati,A ShakeriN FarnoushA Shakeri,Babol University of Medical Sciencesarticleremifentanilisofluraneintraocular pressurecataractplacebohemodynamicMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 5, Pp 16-21 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	remifentanil isoflurane intraocular pressure cataract placebo hemodynamic Medicine R Medicine (General) R5-920
spellingShingle	remifentanil isoflurane intraocular pressure cataract placebo hemodynamic Medicine R Medicine (General) R5-920 MR Ghodrati, A Shakeri N Farnoush A Shakeri, Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane
description	BACKGROUND AND OBJECTIVE: One of the important aims in anesthetic management during ocular surgery is to provide adequate control of intraocular pressure (IOP) and increasing of this pressure would cause some dramatic complications even though visual loss. The aim of this research was to evaluate the effects of adding remifentanil to isoflurane anesthesia on intraocular pressure (IOP) and hemodynamic responses after intubation and during cataract surgery. METHODS: This study was conducted as randomized clinical trial. Forty patients (20 in each group) enrolled and assigned in two group, isoflurane + remifentanil (R), and isoflurane + placebo (P). Anesthesia was induced in both groups with Na-thiopental 5 mg/kg and atracorium 0.5 mg/kg body weight. In group (R), the patients received1 µg/kg as bolus dose of remifentanil and then continuous infusion 0.1 µg/kg/min was started. In placebo group, saline was infused. IOP and mean arterial pressure (MAP) was measured at 8 different times (zero time, after premedication, after induction of anesthesia, immediately 3 and 6 min after intubation, at the end of surgery and 5 min after remifentanil stopping) by a blind surgeon to research. FINDINGS: Primary IOP in group R was 12.7±3.1 mmhg, and in group P was 13.7±3.4 mmHg. After injection of premedication and induction drugs IOP was decreased obviously in two groups. In both groups mean IOP increased after intubation significantly and reach to 12.1±2.8 mmhg and 14.2±3.2 respectively in group R and P that this difference was not significant. Comparison of MAP between two groups only in third measure (after induction of anesthesia) was meaningful (74.6±14.9 in group R and 88.2±14.1 mmhg in group P) (p=0.005).CONCLUSION: This research was shown that adding of remifentanil to isoflurane in cataract anesthesia could prevent from increasing of IOP due to tracheal intubation.
format	article
author	MR Ghodrati, A Shakeri N Farnoush A Shakeri,
author_facet	MR Ghodrati, A Shakeri N Farnoush A Shakeri,
author_sort	MR Ghodrati,
title	Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane
title_short	Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane
title_full	Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane
title_fullStr	Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane
title_full_unstemmed	Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane
title_sort	effect of remifentanil on intra-ocular pressure in cataract surgery under general anesthesia with isoflurane
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/52d99fadef4b49a29848c36e641cdb4a
work_keys_str_mv	AT mrghodrati effectofremifentanilonintraocularpressureincataractsurgeryundergeneralanesthesiawithisoflurane AT ashakeri effectofremifentanilonintraocularpressureincataractsurgeryundergeneralanesthesiawithisoflurane AT nfarnoush effectofremifentanilonintraocularpressureincataractsurgeryundergeneralanesthesiawithisoflurane AT ashakeri effectofremifentanilonintraocularpressureincataractsurgeryundergeneralanesthesiawithisoflurane
_version_	1718440281831899136

Effect of Remifentanil on Intra-Ocular Pressure in Cataract Surgery under General Anesthesia with Isoflurane

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