Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves

Curcuma longa L. is a famous spice cultivated in many countries with significant variations reported in its phytochemical contents and biological potential. For the first time, the present work is aimed to identify the major phytochemicals present in methanol:chloroform (MC) and petroleum ether (PE)...

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Autores principales:	Altir Najah Khalifah Mansour, Ali Ammar Mohammed Ahmed, Gaafar Abdel-Rhman Z., Qahtan Ahmed A., Abdel-Salam Eslam M., Alshameri Aref, Hodhod Mohamed S., Almunqedhi Bander
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	curcuma longa leaves rhizome phytochemicals biological activities. Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/52e28a9ae15b4298828b977d0a4716c4
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spelling	oai:doaj.org-article:52e28a9ae15b4298828b977d0a4716c42021-12-05T14:10:44ZPhytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves2391-542010.1515/chem-2021-0086https://doaj.org/article/52e28a9ae15b4298828b977d0a4716c42021-09-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0086https://doaj.org/toc/2391-5420Curcuma longa L. is a famous spice cultivated in many countries with significant variations reported in its phytochemical contents and biological potential. For the first time, the present work is aimed to identify the major phytochemicals present in methanol:chloroform (MC) and petroleum ether (PE) extracts of Curcuma longa rhizome and leaves (by determining polyphenols and GC/MS analysis), and their in-vitro antioxidant and anti-protein denaturation potential. Results showed that the highest value (P < 0.05) of polyphenolic content was in MC extract of rhizome (51.46 ± 0.46 mg GAE/g) followed by 31.20 ± 0.53 mg GAE/g in MC leaves extract. The strong antiradical activity was evaluated in MC extract of rhizome with IC50 value of 92 ± 0.02 µg/mL. MC extracts of both the rhizome and leaves exerted a potent inhibitory effect against protein denaturation with IC50 values of 106.21 ± 0.53 and 108.06 ± 4.67 μg/mL (P > 0.5), respectively. GC/MS analysis showed that α-tumerone was the main component in the rhizome oil (32.44%), whereas in the leaf oil, palmitic acid was the prominent constituent (28.33%) and α-phellandrene recorded a comparable percentage (7.29). In conclusion, C. longa is a valuable source of natural antioxidants and anti-inflammatory constituents, as indicated by its high polyphenolic content and by its considerable in vitro antiradical and anti-protein denaturation potential.Altir Najah Khalifah MansourAli Ammar Mohammed AhmedGaafar Abdel-Rhman Z.Qahtan Ahmed A.Abdel-Salam Eslam M.Alshameri ArefHodhod Mohamed S.Almunqedhi BanderDe Gruyterarticlecurcuma longaleavesrhizomephytochemicalsbiological activities.ChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 945-952 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcuma longa leaves rhizome phytochemicals biological activities. Chemistry QD1-999
spellingShingle	curcuma longa leaves rhizome phytochemicals biological activities. Chemistry QD1-999 Altir Najah Khalifah Mansour Ali Ammar Mohammed Ahmed Gaafar Abdel-Rhman Z. Qahtan Ahmed A. Abdel-Salam Eslam M. Alshameri Aref Hodhod Mohamed S. Almunqedhi Bander Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves
description	Curcuma longa L. is a famous spice cultivated in many countries with significant variations reported in its phytochemical contents and biological potential. For the first time, the present work is aimed to identify the major phytochemicals present in methanol:chloroform (MC) and petroleum ether (PE) extracts of Curcuma longa rhizome and leaves (by determining polyphenols and GC/MS analysis), and their in-vitro antioxidant and anti-protein denaturation potential. Results showed that the highest value (P < 0.05) of polyphenolic content was in MC extract of rhizome (51.46 ± 0.46 mg GAE/g) followed by 31.20 ± 0.53 mg GAE/g in MC leaves extract. The strong antiradical activity was evaluated in MC extract of rhizome with IC50 value of 92 ± 0.02 µg/mL. MC extracts of both the rhizome and leaves exerted a potent inhibitory effect against protein denaturation with IC50 values of 106.21 ± 0.53 and 108.06 ± 4.67 μg/mL (P > 0.5), respectively. GC/MS analysis showed that α-tumerone was the main component in the rhizome oil (32.44%), whereas in the leaf oil, palmitic acid was the prominent constituent (28.33%) and α-phellandrene recorded a comparable percentage (7.29). In conclusion, C. longa is a valuable source of natural antioxidants and anti-inflammatory constituents, as indicated by its high polyphenolic content and by its considerable in vitro antiradical and anti-protein denaturation potential.
format	article
author	Altir Najah Khalifah Mansour Ali Ammar Mohammed Ahmed Gaafar Abdel-Rhman Z. Qahtan Ahmed A. Abdel-Salam Eslam M. Alshameri Aref Hodhod Mohamed S. Almunqedhi Bander
author_facet	Altir Najah Khalifah Mansour Ali Ammar Mohammed Ahmed Gaafar Abdel-Rhman Z. Qahtan Ahmed A. Abdel-Salam Eslam M. Alshameri Aref Hodhod Mohamed S. Almunqedhi Bander
author_sort	Altir Najah Khalifah Mansour
title	Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves
title_short	Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves
title_full	Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves
title_fullStr	Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves
title_full_unstemmed	Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves
title_sort	phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of curcuma longa l. rhizome and leaves
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/52e28a9ae15b4298828b977d0a4716c4
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Phytochemical profile, in vitro antioxidant, and anti-protein denaturation activities of Curcuma longa L. rhizome and leaves

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