Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice

Mutations that cause tissue mosaicism have been identified in individuals with severe congenital defects. Here, the authors show that mosaic deletion of Vangl2 in the murine neuroepithlium causes spina bifida by preventing apical constriction via reduced myosin II and tubulin organisation.

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Main Authors:	Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/52e4848101894d13b8f2a7a3e588a063
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spelling	oai:doaj.org-article:52e4848101894d13b8f2a7a3e588a0632021-12-02T10:52:47ZCell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice10.1038/s41467-021-21372-42041-1723https://doaj.org/article/52e4848101894d13b8f2a7a3e588a0632021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21372-4https://doaj.org/toc/2041-1723Mutations that cause tissue mosaicism have been identified in individuals with severe congenital defects. Here, the authors show that mosaic deletion of Vangl2 in the murine neuroepithlium causes spina bifida by preventing apical constriction via reduced myosin II and tubulin organisation.Gabriel L. GaleaEirini ManiouTimothy J. EdwardsAbigail R. MarshallIoakeim AmpartzidisNicholas D. E. GreeneAndrew J. CoppNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriel L. Galea Eirini Maniou Timothy J. Edwards Abigail R. Marshall Ioakeim Ampartzidis Nicholas D. E. Greene Andrew J. Copp Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
description	Mutations that cause tissue mosaicism have been identified in individuals with severe congenital defects. Here, the authors show that mosaic deletion of Vangl2 in the murine neuroepithlium causes spina bifida by preventing apical constriction via reduced myosin II and tubulin organisation.
format	article
author	Gabriel L. Galea Eirini Maniou Timothy J. Edwards Abigail R. Marshall Ioakeim Ampartzidis Nicholas D. E. Greene Andrew J. Copp
author_facet	Gabriel L. Galea Eirini Maniou Timothy J. Edwards Abigail R. Marshall Ioakeim Ampartzidis Nicholas D. E. Greene Andrew J. Copp
author_sort	Gabriel L. Galea
title	Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
title_short	Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
title_full	Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
title_fullStr	Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
title_full_unstemmed	Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice
title_sort	cell non-autonomy amplifies disruption of neurulation by mosaic vangl2 deletion in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/52e4848101894d13b8f2a7a3e588a063
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Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice

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