Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery

Design of experiments is used to optimize ratios between deproteinized natural rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent variables as moisture content, moisture uptake, and swelling index in simulated saliva 3 and 5 h. Mathematical models were linear for moi...

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Autores principales:	Suksaeree Jirapornchai, Chaichawawut Benjarut, Srichan Muntira, Tanaboonsuthi Noppamon, Monton Chaowalit, Maneewattanapinyo Pattwat, Pichayakorn Wiwat
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	3d response surface contour plot design of experiments buccal film nicotine delivery Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/52e5175ff5804c24a625b87dd93001c4
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spelling	oai:doaj.org-article:52e5175ff5804c24a625b87dd93001c42021-12-05T14:10:48ZApplying design of experiments (DoE) on the properties of buccal film for nicotine delivery1618-722910.1515/epoly-2021-0064https://doaj.org/article/52e5175ff5804c24a625b87dd93001c42021-08-01T00:00:00Zhttps://doi.org/10.1515/epoly-2021-0064https://doaj.org/toc/1618-7229Design of experiments is used to optimize ratios between deproteinized natural rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent variables as moisture content, moisture uptake, and swelling index in simulated saliva 3 and 5 h. Mathematical models were linear for moisture content and moisture uptake, while swelling index in simulated saliva 3 and 5 h was a quadratic model. Optimized polymer ratio was 0.319:0.362:0.319, respectively. Experimental values were 13.17 ± 0.92%, 3.96 ± 0.84%, 112.58 ± 22.63%, and 124.69 ± 8.01% for dependent variables, respectively. The buccal film showed high swelling at pH 7 and swelling–deswelling behaviors in a water/ethanol environment. The surface pH, weight, and thickness were 8.11, 63.28 ± 6.18 mg, and 219.87 ± 44.28 µm, respectively. Nicotine content was found as 10.22 ± 0.46 mg/4 cm2. Maximum cumulative nicotine release was 9.82 ± 0.94 mg/4 cm2. Kinetic model fitted to the Korsmeyer-Peppas model and release exponent was 0.36, representing that release mechanism was controlled by Fickian diffusion release.Suksaeree JirapornchaiChaichawawut BenjarutSrichan MuntiraTanaboonsuthi NoppamonMonton ChaowalitManeewattanapinyo PattwatPichayakorn WiwatDe Gruyterarticle3d response surfacecontour plotdesign of experimentsbuccal filmnicotine deliveryPolymers and polymer manufactureTP1080-1185ENe-Polymers, Vol 21, Iss 1, Pp 566-574 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3d response surface contour plot design of experiments buccal film nicotine delivery Polymers and polymer manufacture TP1080-1185
spellingShingle	3d response surface contour plot design of experiments buccal film nicotine delivery Polymers and polymer manufacture TP1080-1185 Suksaeree Jirapornchai Chaichawawut Benjarut Srichan Muntira Tanaboonsuthi Noppamon Monton Chaowalit Maneewattanapinyo Pattwat Pichayakorn Wiwat Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
description	Design of experiments is used to optimize ratios between deproteinized natural rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent variables as moisture content, moisture uptake, and swelling index in simulated saliva 3 and 5 h. Mathematical models were linear for moisture content and moisture uptake, while swelling index in simulated saliva 3 and 5 h was a quadratic model. Optimized polymer ratio was 0.319:0.362:0.319, respectively. Experimental values were 13.17 ± 0.92%, 3.96 ± 0.84%, 112.58 ± 22.63%, and 124.69 ± 8.01% for dependent variables, respectively. The buccal film showed high swelling at pH 7 and swelling–deswelling behaviors in a water/ethanol environment. The surface pH, weight, and thickness were 8.11, 63.28 ± 6.18 mg, and 219.87 ± 44.28 µm, respectively. Nicotine content was found as 10.22 ± 0.46 mg/4 cm2. Maximum cumulative nicotine release was 9.82 ± 0.94 mg/4 cm2. Kinetic model fitted to the Korsmeyer-Peppas model and release exponent was 0.36, representing that release mechanism was controlled by Fickian diffusion release.
format	article
author	Suksaeree Jirapornchai Chaichawawut Benjarut Srichan Muntira Tanaboonsuthi Noppamon Monton Chaowalit Maneewattanapinyo Pattwat Pichayakorn Wiwat
author_facet	Suksaeree Jirapornchai Chaichawawut Benjarut Srichan Muntira Tanaboonsuthi Noppamon Monton Chaowalit Maneewattanapinyo Pattwat Pichayakorn Wiwat
author_sort	Suksaeree Jirapornchai
title	Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
title_short	Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
title_full	Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
title_fullStr	Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
title_full_unstemmed	Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
title_sort	applying design of experiments (doe) on the properties of buccal film for nicotine delivery
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/52e5175ff5804c24a625b87dd93001c4
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Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery

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