Chromatin accessibility associates with protein-RNA correlation in human cancer

Studies show the cancer transcriptome correlates poorly with the cancer proteome, questioning the role of chromatin regulation. Here the authors demonstrate proximal-gene-body chromatin elements and transcription predict abundances of differentially expressed proteins in thyroid and breast cancers.

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Autores principales:	Akshay Sanghi, Joshua J. Gruber, Ahmed Metwally, Lihua Jiang, Warren Reynolds, John Sunwoo, Lisa Orloff, Howard Y. Chang, Maya Kasowski, Michael P. Snyder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52e566df74e546f093159fdc1acc7d5c
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spelling	oai:doaj.org-article:52e566df74e546f093159fdc1acc7d5c2021-12-02T18:51:16ZChromatin accessibility associates with protein-RNA correlation in human cancer10.1038/s41467-021-25872-12041-1723https://doaj.org/article/52e566df74e546f093159fdc1acc7d5c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25872-1https://doaj.org/toc/2041-1723Studies show the cancer transcriptome correlates poorly with the cancer proteome, questioning the role of chromatin regulation. Here the authors demonstrate proximal-gene-body chromatin elements and transcription predict abundances of differentially expressed proteins in thyroid and breast cancers.Akshay SanghiJoshua J. GruberAhmed MetwallyLihua JiangWarren ReynoldsJohn SunwooLisa OrloffHoward Y. ChangMaya KasowskiMichael P. SnyderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akshay Sanghi Joshua J. Gruber Ahmed Metwally Lihua Jiang Warren Reynolds John Sunwoo Lisa Orloff Howard Y. Chang Maya Kasowski Michael P. Snyder Chromatin accessibility associates with protein-RNA correlation in human cancer
description	Studies show the cancer transcriptome correlates poorly with the cancer proteome, questioning the role of chromatin regulation. Here the authors demonstrate proximal-gene-body chromatin elements and transcription predict abundances of differentially expressed proteins in thyroid and breast cancers.
format	article
author	Akshay Sanghi Joshua J. Gruber Ahmed Metwally Lihua Jiang Warren Reynolds John Sunwoo Lisa Orloff Howard Y. Chang Maya Kasowski Michael P. Snyder
author_facet	Akshay Sanghi Joshua J. Gruber Ahmed Metwally Lihua Jiang Warren Reynolds John Sunwoo Lisa Orloff Howard Y. Chang Maya Kasowski Michael P. Snyder
author_sort	Akshay Sanghi
title	Chromatin accessibility associates with protein-RNA correlation in human cancer
title_short	Chromatin accessibility associates with protein-RNA correlation in human cancer
title_full	Chromatin accessibility associates with protein-RNA correlation in human cancer
title_fullStr	Chromatin accessibility associates with protein-RNA correlation in human cancer
title_full_unstemmed	Chromatin accessibility associates with protein-RNA correlation in human cancer
title_sort	chromatin accessibility associates with protein-rna correlation in human cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/52e566df74e546f093159fdc1acc7d5c
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Chromatin accessibility associates with protein-RNA correlation in human cancer

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