Chromatin accessibility associates with protein-RNA correlation in human cancer
Studies show the cancer transcriptome correlates poorly with the cancer proteome, questioning the role of chromatin regulation. Here the authors demonstrate proximal-gene-body chromatin elements and transcription predict abundances of differentially expressed proteins in thyroid and breast cancers.
Guardado en:
Autores principales: | Akshay Sanghi, Joshua J. Gruber, Ahmed Metwally, Lihua Jiang, Warren Reynolds, John Sunwoo, Lisa Orloff, Howard Y. Chang, Maya Kasowski, Michael P. Snyder |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/52e566df74e546f093159fdc1acc7d5c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Spatially mapped single-cell chromatin accessibility
por: Casey A. Thornton, et al.
Publicado: (2021) -
Profiling Chromatin Accessibility at Single-cell Resolution
por: Sarthak Sinha, et al.
Publicado: (2021) -
Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation
por: Qian Zhang, et al.
Publicado: (2021) -
Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in Müller Glial regenerative potential
por: Leah S. VandenBosch, et al.
Publicado: (2020) -
Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
por: Qian Liu, et al.
Publicado: (2020)