Chromatin accessibility associates with protein-RNA correlation in human cancer

Studies show the cancer transcriptome correlates poorly with the cancer proteome, questioning the role of chromatin regulation. Here the authors demonstrate proximal-gene-body chromatin elements and transcription predict abundances of differentially expressed proteins in thyroid and breast cancers.

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Autores principales: Akshay Sanghi, Joshua J. Gruber, Ahmed Metwally, Lihua Jiang, Warren Reynolds, John Sunwoo, Lisa Orloff, Howard Y. Chang, Maya Kasowski, Michael P. Snyder
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/52e566df74e546f093159fdc1acc7d5c
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