DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner

Formation of γH2Ax serves as a checkpoint for double-strand break (DSB) repair pathways. Here the authors reveal via integrated chromatin analysis that γH2Ax domains are established by chromosomal contacts with the DSB site.

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Autores principales:	Patrick L. Collins, Caitlin Purman, Sofia I. Porter, Vincent Nganga, Ankita Saini, Katharina E. Hayer, Greer L. Gurewitz, Barry P. Sleckman, Jeffrey J. Bednarski, Craig H. Bassing, Eugene M. Oltz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52e96531818443018246302cc0d348bc
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spelling	oai:doaj.org-article:52e96531818443018246302cc0d348bc2021-12-02T16:05:51ZDNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner10.1038/s41467-020-16926-x2041-1723https://doaj.org/article/52e96531818443018246302cc0d348bc2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16926-xhttps://doaj.org/toc/2041-1723Formation of γH2Ax serves as a checkpoint for double-strand break (DSB) repair pathways. Here the authors reveal via integrated chromatin analysis that γH2Ax domains are established by chromosomal contacts with the DSB site.Patrick L. CollinsCaitlin PurmanSofia I. PorterVincent NgangaAnkita SainiKatharina E. HayerGreer L. GurewitzBarry P. SleckmanJeffrey J. BednarskiCraig H. BassingEugene M. OltzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick L. Collins Caitlin Purman Sofia I. Porter Vincent Nganga Ankita Saini Katharina E. Hayer Greer L. Gurewitz Barry P. Sleckman Jeffrey J. Bednarski Craig H. Bassing Eugene M. Oltz DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
description	Formation of γH2Ax serves as a checkpoint for double-strand break (DSB) repair pathways. Here the authors reveal via integrated chromatin analysis that γH2Ax domains are established by chromosomal contacts with the DSB site.
format	article
author	Patrick L. Collins Caitlin Purman Sofia I. Porter Vincent Nganga Ankita Saini Katharina E. Hayer Greer L. Gurewitz Barry P. Sleckman Jeffrey J. Bednarski Craig H. Bassing Eugene M. Oltz
author_facet	Patrick L. Collins Caitlin Purman Sofia I. Porter Vincent Nganga Ankita Saini Katharina E. Hayer Greer L. Gurewitz Barry P. Sleckman Jeffrey J. Bednarski Craig H. Bassing Eugene M. Oltz
author_sort	Patrick L. Collins
title	DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
title_short	DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
title_full	DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
title_fullStr	DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
title_full_unstemmed	DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
title_sort	dna double-strand breaks induce h2ax phosphorylation domains in a contact-dependent manner
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/52e96531818443018246302cc0d348bc
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DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner

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