The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.

<h4>Background</h4>Francisella tularensis is an intercellular bacterium often causing fatal disease when inhaled. Previous reports have underlined the role of cell-mediated immunity and IFNgamma in the host response to Francisella tularensis infection.<h4>Methodology/principal find...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gal Markel, Erez Bar-Haim, Eran Zahavy, Hila Cohen, Ofer Cohen, Avigdor Shafferman, Baruch Velan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/52ea3ed01f0e4842ae8bc8b98e357db5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:52ea3ed01f0e4842ae8bc8b98e357db5
record_format	dspace
spelling	oai:doaj.org-article:52ea3ed01f0e4842ae8bc8b98e357db52021-12-02T20:20:41ZThe involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.1932-620310.1371/journal.pone.0011176https://doaj.org/article/52ea3ed01f0e4842ae8bc8b98e357db52010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20585449/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Francisella tularensis is an intercellular bacterium often causing fatal disease when inhaled. Previous reports have underlined the role of cell-mediated immunity and IFNgamma in the host response to Francisella tularensis infection.<h4>Methodology/principal findings</h4>Here we provide evidence for the involvement of IL-17A in host defense to inhalational tularemia, using a mouse model of intranasal infection with the Live Vaccine Strain (LVS). We demonstrate the kinetics of IL-17A production in lavage fluids of infected lungs and identify the IL-17A-producing lymphocytes as pulmonary gammadelta and Th17 cells. The peak of IL-17A production appears early during sub-lethal infection, it precedes the peak of immune activation and the nadir of the disease, and then subsides subsequently. Exogenous airway administration of IL-17A or of IL-23 had a limited yet consistent effect of delaying the onset of death from a lethal dose of LVS, implying that IL-17A may be involved in restraining the infection. The protective role for IL-17A was directly demonstrated by in vivo neutralization of IL-17A. Administration of anti IL-17A antibodies concomitantly to a sub-lethal airway infection with 0.1xLD(50) resulted in a fatal disease.<h4>Conclusion</h4>In summary, these data characterize the involvement and underline the protective key role of the IL-17A axis in the lungs from inhalational tularemia.Gal MarkelErez Bar-HaimEran ZahavyHila CohenOfer CohenAvigdor ShaffermanBaruch VelanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 6, p e11176 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gal Markel Erez Bar-Haim Eran Zahavy Hila Cohen Ofer Cohen Avigdor Shafferman Baruch Velan The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
description	<h4>Background</h4>Francisella tularensis is an intercellular bacterium often causing fatal disease when inhaled. Previous reports have underlined the role of cell-mediated immunity and IFNgamma in the host response to Francisella tularensis infection.<h4>Methodology/principal findings</h4>Here we provide evidence for the involvement of IL-17A in host defense to inhalational tularemia, using a mouse model of intranasal infection with the Live Vaccine Strain (LVS). We demonstrate the kinetics of IL-17A production in lavage fluids of infected lungs and identify the IL-17A-producing lymphocytes as pulmonary gammadelta and Th17 cells. The peak of IL-17A production appears early during sub-lethal infection, it precedes the peak of immune activation and the nadir of the disease, and then subsides subsequently. Exogenous airway administration of IL-17A or of IL-23 had a limited yet consistent effect of delaying the onset of death from a lethal dose of LVS, implying that IL-17A may be involved in restraining the infection. The protective role for IL-17A was directly demonstrated by in vivo neutralization of IL-17A. Administration of anti IL-17A antibodies concomitantly to a sub-lethal airway infection with 0.1xLD(50) resulted in a fatal disease.<h4>Conclusion</h4>In summary, these data characterize the involvement and underline the protective key role of the IL-17A axis in the lungs from inhalational tularemia.
format	article
author	Gal Markel Erez Bar-Haim Eran Zahavy Hila Cohen Ofer Cohen Avigdor Shafferman Baruch Velan
author_facet	Gal Markel Erez Bar-Haim Eran Zahavy Hila Cohen Ofer Cohen Avigdor Shafferman Baruch Velan
author_sort	Gal Markel
title	The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
title_short	The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
title_full	The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
title_fullStr	The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
title_full_unstemmed	The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
title_sort	involvement of il-17a in the murine response to sub-lethal inhalational infection with francisella tularensis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/52ea3ed01f0e4842ae8bc8b98e357db5
work_keys_str_mv	AT galmarkel theinvolvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT erezbarhaim theinvolvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT eranzahavy theinvolvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT hilacohen theinvolvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT ofercohen theinvolvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT avigdorshafferman theinvolvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT baruchvelan theinvolvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT galmarkel involvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT erezbarhaim involvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT eranzahavy involvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT hilacohen involvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT ofercohen involvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT avigdorshafferman involvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis AT baruchvelan involvementofil17ainthemurineresponsetosublethalinhalationalinfectionwithfrancisellatularensis
_version_	1718374164638728192

The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.

Ejemplares similares