Oxygen as a Virulence Determinant in Polymicrobial Infections

ABSTRACT Infections caused by multiple organisms, or polymicrobial infections, are likely more common than is broadly appreciated. Interaction among microbial communities (and with their host) can change the infection landscape by subverting immunity, providing nutrients and inhibiting competing mic...

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Autores principales:	Elizabeth M. Selleck, Michael S. Gilmore
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/52ebf317a0fc43b7bf815281152c696c
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spelling	oai:doaj.org-article:52ebf317a0fc43b7bf815281152c696c2021-11-15T15:50:19ZOxygen as a Virulence Determinant in Polymicrobial Infections10.1128/mBio.01249-162150-7511https://doaj.org/article/52ebf317a0fc43b7bf815281152c696c2016-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01249-16https://doaj.org/toc/2150-7511ABSTRACT Infections caused by multiple organisms, or polymicrobial infections, are likely more common than is broadly appreciated. Interaction among microbial communities (and with their host) can change the infection landscape by subverting immunity, providing nutrients and inhibiting competing microbes. Stacy et al. (A. Stacy, D. Fleming, R. J. Lamont, K. P. Rumbaugh, and M. Whiteley, mBio 7:e00782-16, 2016, http://dx.doi.org/10.1128/mBio.00782-16) described a novel mechanism that results in synergistic growth of oral microbes Aggregatibacter actinomycetemcomitans and Streptococcus gordonii. The authors used whole-genome fitness profiling by transposon sequencing (Tn-seq) to identify genes differentially required for growth in vitro versus in a mono- or coinfection in a thigh abscess model. They found that coinfection with S. gordonii allowed A. actinomycetemcomitans to shift from an anaerobic to an aerobic mode of growth. This shift involved the production of a terminal electron acceptor H2O2 by S. gordonii and increased A. actinomycetemcomitans persistence—an interaction termed “cross-respiration.”Elizabeth M. SelleckMichael S. GilmoreAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 4 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Elizabeth M. Selleck Michael S. Gilmore Oxygen as a Virulence Determinant in Polymicrobial Infections
description	ABSTRACT Infections caused by multiple organisms, or polymicrobial infections, are likely more common than is broadly appreciated. Interaction among microbial communities (and with their host) can change the infection landscape by subverting immunity, providing nutrients and inhibiting competing microbes. Stacy et al. (A. Stacy, D. Fleming, R. J. Lamont, K. P. Rumbaugh, and M. Whiteley, mBio 7:e00782-16, 2016, http://dx.doi.org/10.1128/mBio.00782-16) described a novel mechanism that results in synergistic growth of oral microbes Aggregatibacter actinomycetemcomitans and Streptococcus gordonii. The authors used whole-genome fitness profiling by transposon sequencing (Tn-seq) to identify genes differentially required for growth in vitro versus in a mono- or coinfection in a thigh abscess model. They found that coinfection with S. gordonii allowed A. actinomycetemcomitans to shift from an anaerobic to an aerobic mode of growth. This shift involved the production of a terminal electron acceptor H2O2 by S. gordonii and increased A. actinomycetemcomitans persistence—an interaction termed “cross-respiration.”
format	article
author	Elizabeth M. Selleck Michael S. Gilmore
author_facet	Elizabeth M. Selleck Michael S. Gilmore
author_sort	Elizabeth M. Selleck
title	Oxygen as a Virulence Determinant in Polymicrobial Infections
title_short	Oxygen as a Virulence Determinant in Polymicrobial Infections
title_full	Oxygen as a Virulence Determinant in Polymicrobial Infections
title_fullStr	Oxygen as a Virulence Determinant in Polymicrobial Infections
title_full_unstemmed	Oxygen as a Virulence Determinant in Polymicrobial Infections
title_sort	oxygen as a virulence determinant in polymicrobial infections
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/52ebf317a0fc43b7bf815281152c696c
work_keys_str_mv	AT elizabethmselleck oxygenasavirulencedeterminantinpolymicrobialinfections AT michaelsgilmore oxygenasavirulencedeterminantinpolymicrobialinfections
_version_	1718427397761531904

Oxygen as a Virulence Determinant in Polymicrobial Infections

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