Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study

Yi Shao,1,* Feng-Qin Cai,2,* Yu-Lin Zhong,1 Xin Huang,1,3 Ying Zhang,1 Pei-Hong Hu,1 Chong-Gang Pei,1 Fu-Qing Zhou,2 Xian-Jun Zeng2 1Department of Ophthalmology, 2Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, 3Department of Ophthalmology, First People&rsqu...

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Autores principales:	Shao Y, Cai FQ, Zhong YL, Huang X, Zhang Y, Hu PH, Pei CG, Zhou FQ, Zeng XJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Optic neuritis Regional homogeneity Functional magnetic resonance imaging Resting state; Visual evoked potential Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/52ec406995714136888f4a18659b7844
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spelling	oai:doaj.org-article:52ec406995714136888f4a18659b78442021-12-02T03:44:21ZAltered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study1178-2021https://doaj.org/article/52ec406995714136888f4a18659b78442015-12-01T00:00:00Zhttps://www.dovepress.com/altered-intrinsic-regional-spontaneous-brain-activity-in-patients-with-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yi Shao,1,* Feng-Qin Cai,2,* Yu-Lin Zhong,1 Xin Huang,1,3 Ying Zhang,1 Pei-Hong Hu,1 Chong-Gang Pei,1 Fu-Qing Zhou,2 Xian-Jun Zeng2 1Department of Ophthalmology, 2Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, 3Department of Ophthalmology, First People’s Hospital of Jiujiang, Jiujiang, People’s Republic of China *These authors contributed equally to this work Objective: To investigate the underlying regional homogeneity (ReHo) in brain-activity deficit in patients with optic neuritis (ON) and its relationship with behavioral performance.Materials and methods: In total, twelve patients with ON (four males and eight females) and twelve (four males and eight females) age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess the local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the visual evoked potential (VEP) in patients with ON.Results: Compared with the healthy controls, patients with ON showed lower ReHo in the left cerebellum, posterior lobe, left middle temporal gyrus, right insula, right superior temporal gyrus, left middle frontal gyrus, bilateral anterior cingulate cortex, left superior frontal gyrus, right superior frontal gyrus, and right precentral gyrus, and higher ReHo in the cluster of the left fusiform gyrus and right inferior parietal lobule. Meanwhile, we found that the VEP amplitude of the right eye in patients with ON showed a positive correlation with the ReHo signal value of the left cerebellum posterior lobe (r=0.701, P=0.011), the right superior frontal gyrus (r=0.731, P=0.007), and the left fusiform gyrus (r=0.644, P=0.024). We also found that the VEP latency of the right eye in ON showed a positive correlation with the ReHo signal value of the right insula (r=0.595, P=0.041).Conclusion: ON may involve dysfunction in the default-mode network, which may reflect the underlying pathologic mechanism. Keywords: optic neuritis, regional homogeneity, rs-fMRI, visual evoked potential Shao YCai FQZhong YLHuang XZhang YHu PHPei CGZhou FQZeng XJDove Medical PressarticleOptic neuritis Regional homogeneity Functional magnetic resonance imaging Resting state; Visual evoked potentialNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss Issue 1, Pp 3065-3073 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Optic neuritis Regional homogeneity Functional magnetic resonance imaging Resting state; Visual evoked potential Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Optic neuritis Regional homogeneity Functional magnetic resonance imaging Resting state; Visual evoked potential Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shao Y Cai FQ Zhong YL Huang X Zhang Y Hu PH Pei CG Zhou FQ Zeng XJ Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study
description	Yi Shao,1,* Feng-Qin Cai,2,* Yu-Lin Zhong,1 Xin Huang,1,3 Ying Zhang,1 Pei-Hong Hu,1 Chong-Gang Pei,1 Fu-Qing Zhou,2 Xian-Jun Zeng2 1Department of Ophthalmology, 2Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, 3Department of Ophthalmology, First People’s Hospital of Jiujiang, Jiujiang, People’s Republic of China *These authors contributed equally to this work Objective: To investigate the underlying regional homogeneity (ReHo) in brain-activity deficit in patients with optic neuritis (ON) and its relationship with behavioral performance.Materials and methods: In total, twelve patients with ON (four males and eight females) and twelve (four males and eight females) age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess the local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the visual evoked potential (VEP) in patients with ON.Results: Compared with the healthy controls, patients with ON showed lower ReHo in the left cerebellum, posterior lobe, left middle temporal gyrus, right insula, right superior temporal gyrus, left middle frontal gyrus, bilateral anterior cingulate cortex, left superior frontal gyrus, right superior frontal gyrus, and right precentral gyrus, and higher ReHo in the cluster of the left fusiform gyrus and right inferior parietal lobule. Meanwhile, we found that the VEP amplitude of the right eye in patients with ON showed a positive correlation with the ReHo signal value of the left cerebellum posterior lobe (r=0.701, P=0.011), the right superior frontal gyrus (r=0.731, P=0.007), and the left fusiform gyrus (r=0.644, P=0.024). We also found that the VEP latency of the right eye in ON showed a positive correlation with the ReHo signal value of the right insula (r=0.595, P=0.041).Conclusion: ON may involve dysfunction in the default-mode network, which may reflect the underlying pathologic mechanism. Keywords: optic neuritis, regional homogeneity, rs-fMRI, visual evoked potential
format	article
author	Shao Y Cai FQ Zhong YL Huang X Zhang Y Hu PH Pei CG Zhou FQ Zeng XJ
author_facet	Shao Y Cai FQ Zhong YL Huang X Zhang Y Hu PH Pei CG Zhou FQ Zeng XJ
author_sort	Shao Y
title	Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study
title_short	Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study
title_full	Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study
title_fullStr	Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study
title_full_unstemmed	Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study
title_sort	altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/52ec406995714136888f4a18659b7844
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Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study

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