The common origin of symmetry and structure in genetic sequences

Abstract Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On the other hand, single-strand symmetry has been sc...

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Autores principales:	Giampaolo Cristadoro, Mirko Degli Esposti, Eduardo G. Altmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Simple Domain Model Complex Genomic Organization Chargaff Typical Cluster Size Symmetry-related Pairs Medicine R Science Q
Acceso en línea:	https://doaj.org/article/52eda29828df448cb4e46d0353448ae0
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spelling	oai:doaj.org-article:52eda29828df448cb4e46d0353448ae02021-12-02T11:40:25ZThe common origin of symmetry and structure in genetic sequences10.1038/s41598-018-34136-w2045-2322https://doaj.org/article/52eda29828df448cb4e46d0353448ae02018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34136-whttps://doaj.org/toc/2045-2322Abstract Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On the other hand, single-strand symmetry has been scrutinised using neutral models in which correlations are not considered or irrelevant, contrary to empirical evidence. Different studies investigated these two statistical features separately, reaching minimal consensus despite sustained efforts. Here we unravel previously unknown symmetries in genetic sequences, which are organized hierarchically through scales in which non-random structures are known to be present. These observations are confirmed through the statistical analysis of the human genome and explained through a simple domain model. These results suggest that domain models which account for the cumulative action of mobile elements can explain simultaneously non-random structures and symmetries in genetic sequences.Giampaolo CristadoroMirko Degli EspostiEduardo G. AltmannNature PortfolioarticleSimple Domain ModelComplex Genomic OrganizationChargaffTypical Cluster SizeSymmetry-related PairsMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Simple Domain Model Complex Genomic Organization Chargaff Typical Cluster Size Symmetry-related Pairs Medicine R Science Q
spellingShingle	Simple Domain Model Complex Genomic Organization Chargaff Typical Cluster Size Symmetry-related Pairs Medicine R Science Q Giampaolo Cristadoro Mirko Degli Esposti Eduardo G. Altmann The common origin of symmetry and structure in genetic sequences
description	Abstract Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On the other hand, single-strand symmetry has been scrutinised using neutral models in which correlations are not considered or irrelevant, contrary to empirical evidence. Different studies investigated these two statistical features separately, reaching minimal consensus despite sustained efforts. Here we unravel previously unknown symmetries in genetic sequences, which are organized hierarchically through scales in which non-random structures are known to be present. These observations are confirmed through the statistical analysis of the human genome and explained through a simple domain model. These results suggest that domain models which account for the cumulative action of mobile elements can explain simultaneously non-random structures and symmetries in genetic sequences.
format	article
author	Giampaolo Cristadoro Mirko Degli Esposti Eduardo G. Altmann
author_facet	Giampaolo Cristadoro Mirko Degli Esposti Eduardo G. Altmann
author_sort	Giampaolo Cristadoro
title	The common origin of symmetry and structure in genetic sequences
title_short	The common origin of symmetry and structure in genetic sequences
title_full	The common origin of symmetry and structure in genetic sequences
title_fullStr	The common origin of symmetry and structure in genetic sequences
title_full_unstemmed	The common origin of symmetry and structure in genetic sequences
title_sort	common origin of symmetry and structure in genetic sequences
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/52eda29828df448cb4e46d0353448ae0
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_version_	1718395642149076992

The common origin of symmetry and structure in genetic sequences

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