Generation of Skin Organoids: Potential Opportunities and Challenges

Although several types of human skin substitutes are currently available, they usually do not include important skin appendages such as hair follicles and sweat glands, or various skin-related cells, such as dermal adipocytes and sensory neurons. This highlights the need to improve the in vitro huma...

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Autores principales:	Hui Sun, Yi-Xuan Zhang, Yu-Mei Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	skin organoid skin stem cell niches 3D culture single-cell RNA sequencing skin generation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/52ef55dbef094bdc91fddfe8a24f8858
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spelling	oai:doaj.org-article:52ef55dbef094bdc91fddfe8a24f88582021-11-04T07:18:33ZGeneration of Skin Organoids: Potential Opportunities and Challenges2296-634X10.3389/fcell.2021.709824https://doaj.org/article/52ef55dbef094bdc91fddfe8a24f88582021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.709824/fullhttps://doaj.org/toc/2296-634XAlthough several types of human skin substitutes are currently available, they usually do not include important skin appendages such as hair follicles and sweat glands, or various skin-related cells, such as dermal adipocytes and sensory neurons. This highlights the need to improve the in vitro human skin generation model for use as a tool for investigating skin diseases and as a source of cells or tissues for skin regeneration. Skin organoids are generated from stem cells and are expected to possess the complexity and function of natural skin. Here, we summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and then discuss the opportunities and challenges associated with multifunctional skin organoids.Hui SunHui SunHui SunYi-Xuan ZhangYi-Xuan ZhangYi-Xuan ZhangYu-Mei LiYu-Mei LiYu-Mei LiFrontiers Media S.A.articleskin organoidskin stem cell niches3D culturesingle-cell RNA sequencingskin generationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin organoid skin stem cell niches 3D culture single-cell RNA sequencing skin generation Biology (General) QH301-705.5
spellingShingle	skin organoid skin stem cell niches 3D culture single-cell RNA sequencing skin generation Biology (General) QH301-705.5 Hui Sun Hui Sun Hui Sun Yi-Xuan Zhang Yi-Xuan Zhang Yi-Xuan Zhang Yu-Mei Li Yu-Mei Li Yu-Mei Li Generation of Skin Organoids: Potential Opportunities and Challenges
description	Although several types of human skin substitutes are currently available, they usually do not include important skin appendages such as hair follicles and sweat glands, or various skin-related cells, such as dermal adipocytes and sensory neurons. This highlights the need to improve the in vitro human skin generation model for use as a tool for investigating skin diseases and as a source of cells or tissues for skin regeneration. Skin organoids are generated from stem cells and are expected to possess the complexity and function of natural skin. Here, we summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and then discuss the opportunities and challenges associated with multifunctional skin organoids.
format	article
author	Hui Sun Hui Sun Hui Sun Yi-Xuan Zhang Yi-Xuan Zhang Yi-Xuan Zhang Yu-Mei Li Yu-Mei Li Yu-Mei Li
author_facet	Hui Sun Hui Sun Hui Sun Yi-Xuan Zhang Yi-Xuan Zhang Yi-Xuan Zhang Yu-Mei Li Yu-Mei Li Yu-Mei Li
author_sort	Hui Sun
title	Generation of Skin Organoids: Potential Opportunities and Challenges
title_short	Generation of Skin Organoids: Potential Opportunities and Challenges
title_full	Generation of Skin Organoids: Potential Opportunities and Challenges
title_fullStr	Generation of Skin Organoids: Potential Opportunities and Challenges
title_full_unstemmed	Generation of Skin Organoids: Potential Opportunities and Challenges
title_sort	generation of skin organoids: potential opportunities and challenges
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/52ef55dbef094bdc91fddfe8a24f8858
work_keys_str_mv	AT huisun generationofskinorganoidspotentialopportunitiesandchallenges AT huisun generationofskinorganoidspotentialopportunitiesandchallenges AT huisun generationofskinorganoidspotentialopportunitiesandchallenges AT yixuanzhang generationofskinorganoidspotentialopportunitiesandchallenges AT yixuanzhang generationofskinorganoidspotentialopportunitiesandchallenges AT yixuanzhang generationofskinorganoidspotentialopportunitiesandchallenges AT yumeili generationofskinorganoidspotentialopportunitiesandchallenges AT yumeili generationofskinorganoidspotentialopportunitiesandchallenges AT yumeili generationofskinorganoidspotentialopportunitiesandchallenges
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Generation of Skin Organoids: Potential Opportunities and Challenges

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