Monocytes secrete CXCL7 to promote breast cancer progression

Abstract Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi-Hsiang Wang, Chia-Yi Shen, Sheng-Chieh Lin, Wen-Hung Kuo, Yuan-Ting Kuo, Yu-Ling Hsu, Wen-Ching Wang, Kai-Ti Lin, Lu-Hai Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/52f17cfc91744cd1ae866fd8dc136689
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:52f17cfc91744cd1ae866fd8dc136689
record_format	dspace
spelling	oai:doaj.org-article:52f17cfc91744cd1ae866fd8dc1366892021-11-21T12:03:33ZMonocytes secrete CXCL7 to promote breast cancer progression10.1038/s41419-021-04231-42041-4889https://doaj.org/article/52f17cfc91744cd1ae866fd8dc1366892021-11-01T00:00:00Zhttps://doi.org/10.1038/s41419-021-04231-4https://doaj.org/toc/2041-4889Abstract Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as one of the increasingly secreted cytokines by THP-1 cells. Further investigations indicated that upon co-culturing, breast cancer cells secreted CSF1 to induce expression and release of CXCL7 from monocytes, which in turn acted on cancer cells to promote FAK activation, MMP13 expression, migration, and invasion. In a xenograft mouse model, administration of CXCL7 antibodies significantly reduced abundance of M2 macrophages in tumor microenvironment, as well as decreased tumor growth and distant metastasis. Clinical investigation further suggested that high CXCL7 expression is correlated with breast cancer progression and poor overall survival of patients. Overall, our study unveils an important immune cytokine, CXCL7, which is secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression.Yi-Hsiang WangChia-Yi ShenSheng-Chieh LinWen-Hung KuoYuan-Ting KuoYu-Ling HsuWen-Ching WangKai-Ti LinLu-Hai WangNature Publishing GrouparticleCytologyQH573-671ENCell Death and Disease, Vol 12, Iss 12, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Yi-Hsiang Wang Chia-Yi Shen Sheng-Chieh Lin Wen-Hung Kuo Yuan-Ting Kuo Yu-Ling Hsu Wen-Ching Wang Kai-Ti Lin Lu-Hai Wang Monocytes secrete CXCL7 to promote breast cancer progression
description	Abstract Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as one of the increasingly secreted cytokines by THP-1 cells. Further investigations indicated that upon co-culturing, breast cancer cells secreted CSF1 to induce expression and release of CXCL7 from monocytes, which in turn acted on cancer cells to promote FAK activation, MMP13 expression, migration, and invasion. In a xenograft mouse model, administration of CXCL7 antibodies significantly reduced abundance of M2 macrophages in tumor microenvironment, as well as decreased tumor growth and distant metastasis. Clinical investigation further suggested that high CXCL7 expression is correlated with breast cancer progression and poor overall survival of patients. Overall, our study unveils an important immune cytokine, CXCL7, which is secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression.
format	article
author	Yi-Hsiang Wang Chia-Yi Shen Sheng-Chieh Lin Wen-Hung Kuo Yuan-Ting Kuo Yu-Ling Hsu Wen-Ching Wang Kai-Ti Lin Lu-Hai Wang
author_facet	Yi-Hsiang Wang Chia-Yi Shen Sheng-Chieh Lin Wen-Hung Kuo Yuan-Ting Kuo Yu-Ling Hsu Wen-Ching Wang Kai-Ti Lin Lu-Hai Wang
author_sort	Yi-Hsiang Wang
title	Monocytes secrete CXCL7 to promote breast cancer progression
title_short	Monocytes secrete CXCL7 to promote breast cancer progression
title_full	Monocytes secrete CXCL7 to promote breast cancer progression
title_fullStr	Monocytes secrete CXCL7 to promote breast cancer progression
title_full_unstemmed	Monocytes secrete CXCL7 to promote breast cancer progression
title_sort	monocytes secrete cxcl7 to promote breast cancer progression
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/52f17cfc91744cd1ae866fd8dc136689
work_keys_str_mv	AT yihsiangwang monocytessecretecxcl7topromotebreastcancerprogression AT chiayishen monocytessecretecxcl7topromotebreastcancerprogression AT shengchiehlin monocytessecretecxcl7topromotebreastcancerprogression AT wenhungkuo monocytessecretecxcl7topromotebreastcancerprogression AT yuantingkuo monocytessecretecxcl7topromotebreastcancerprogression AT yulinghsu monocytessecretecxcl7topromotebreastcancerprogression AT wenchingwang monocytessecretecxcl7topromotebreastcancerprogression AT kaitilin monocytessecretecxcl7topromotebreastcancerprogression AT luhaiwang monocytessecretecxcl7topromotebreastcancerprogression
_version_	1718419302835552256

Monocytes secrete CXCL7 to promote breast cancer progression

Ejemplares similares