Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain.

The synthesis of inactive enzyme precursors, also known as "zymogens," serves as a mechanism for regulating the execution of selected catalytic activities in a desirable time and/or site. Zymogens are usually activated by proteolytic cleavage. Many viruses encode proteases that execute key...

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Autores principales: Assaf Shapira, Meital Gal-Tanamy, Limor Nahary, Dana Litvak-Greenfeld, Romy Zemel, Ran Tur-Kaspa, Itai Benhar
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/52f1c18b1d9a4efdb713441d923e9515
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