Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis

Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis

Kuo-Hsuan Hung,1– 3 Yu-Hsiang Lan,2,4 Jui-Yen Lin,1,2 Eugene Yu-Chuan Kang,1,2 Hsin-Yuan Tan,1,2 Hung-Chi Chen,1,2 Ching-Hsi Hsiao,1,2 Lung-Kun Yeh1,2 1Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan, 333, Taiwan; 2Chang-Gung University, College of Medicine, Taoy...

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Autores principales: Hung KH, Lan YH, Lin JY, Kang EYC, Tan HY, Chen HC, Hsiao CH, Yeh LK
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
blepharitis
demodex mites
herpetic keratitis
ocular demodicosis
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/52f4190773564fe0ac2757212fc5e160
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spelling oai:doaj.org-article:52f4190773564fe0ac2757212fc5e1602021-12-02T13:54:52ZPotential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis1177-5483https://doaj.org/article/52f4190773564fe0ac2757212fc5e1602020-12-01T00:00:00Zhttps://www.dovepress.com/potential-role-and-significance-of-ocular-demodicosis-in-patients-with-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kuo-Hsuan Hung,1– 3 Yu-Hsiang Lan,2,4 Jui-Yen Lin,1,2 Eugene Yu-Chuan Kang,1,2 Hsin-Yuan Tan,1,2 Hung-Chi Chen,1,2 Ching-Hsi Hsiao,1,2 Lung-Kun Yeh1,2 1Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan, 333, Taiwan; 2Chang-Gung University, College of Medicine, Taoyuan 333, Taiwan; 3Institute of Clinical Medicine, National Yang-Ming University, Taipei City 112, Taiwan; 4Department of Medicine, Chang Gung University, Taoyuan 333, TaiwanCorrespondence: Lung-Kun YehDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No 5, Fusing St., Taoyuan 333, TaiwanTel +886-3-3281200, ext. 8666Fax +886-3-3287798Email yehlungkun@gmail.comPurpose: To evaluate the role of Demodex infestation of the eyelids in patients with recurrent herpetic keratitis.Patients and Methods: This is a retrospective and noncomparative case series. Twenty-seven patients with ocular demodicosis and recurrent herpetic keratitis under conventional treatments were enrolled. Demographic data and clinical photographs were collected. Ocular demodicosis was confirmed by eyelash examination under a microscope. Eyelid scrub was initiated in these patients after proving Demodex infestation. Response after treatment was reviewed.Results: Herpetic keratitis was characterized by epithelial defect, including dendritic lesions (seven eyes, 25.9%), geographic ulcer (three eyes, 11.1%), and neurotrophic ulcer (two eyes, 7.4%), associated with stromal involvement in 12 cases. Six cases with stromal reactivation, including disciform keratitis (two eyes, 7.4%), immune ring (three eyes, 11.1%), and ghost vessel (one eye, 3.7%), presented no epithelial defect. Active anterior uveitis with keratic precipitates was found in 15 cases. Demodex blepharitis was diagnosed with cylindrical dandruff along their lashes in all patients. Other ocular findings include meibomian gland dysfunction (15 eyes, 55.6%), mal-aligned lashes (eight eyes, 29.6%), telangiectasia (14 eyes, 51.9%), conjunctivitis (18 eyes, 66.7%), and ocular rosacea (three eyes, 11.1%). Initial unstable clinical presentations showed deterioration of corneal melting into descemetocele, corneal perforation, recalcitrant stromal infiltration/uveitis, and uncontrollable IOP, despite antiherpetic medication. After treatment of Demodex blepharitis, infestation was under control, followed by subjective improvement of ocular symptoms and a stable clinical outcome.Conclusion: Ocular demodicosis should be considered in patients with unstable recurrent herpetic keratitis. A prompt diagnosis and appropriate treatment may curb the progression of herpetic corneal infection.Keywords: blepharitis, Demodex mites, herpetic keratitis, ocular demodicosisHung KHLan YHLin JYKang EYCTan HYChen HCHsiao CHYeh LKDove Medical Pressarticleblepharitisdemodex mitesherpetic keratitisocular demodicosisOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 4469-4482 (2020)
institution DOAJ
collection DOAJ
language EN
topic blepharitis
demodex mites
herpetic keratitis
ocular demodicosis
Ophthalmology
RE1-994
spellingShingle blepharitis
demodex mites
herpetic keratitis
ocular demodicosis
Ophthalmology
RE1-994
Hung KH
Lan YH
Lin JY
Kang EYC
Tan HY
Chen HC
Hsiao CH
Yeh LK
Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis
description Kuo-Hsuan Hung,1– 3 Yu-Hsiang Lan,2,4 Jui-Yen Lin,1,2 Eugene Yu-Chuan Kang,1,2 Hsin-Yuan Tan,1,2 Hung-Chi Chen,1,2 Ching-Hsi Hsiao,1,2 Lung-Kun Yeh1,2 1Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan, 333, Taiwan; 2Chang-Gung University, College of Medicine, Taoyuan 333, Taiwan; 3Institute of Clinical Medicine, National Yang-Ming University, Taipei City 112, Taiwan; 4Department of Medicine, Chang Gung University, Taoyuan 333, TaiwanCorrespondence: Lung-Kun YehDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No 5, Fusing St., Taoyuan 333, TaiwanTel +886-3-3281200, ext. 8666Fax +886-3-3287798Email yehlungkun@gmail.comPurpose: To evaluate the role of Demodex infestation of the eyelids in patients with recurrent herpetic keratitis.Patients and Methods: This is a retrospective and noncomparative case series. Twenty-seven patients with ocular demodicosis and recurrent herpetic keratitis under conventional treatments were enrolled. Demographic data and clinical photographs were collected. Ocular demodicosis was confirmed by eyelash examination under a microscope. Eyelid scrub was initiated in these patients after proving Demodex infestation. Response after treatment was reviewed.Results: Herpetic keratitis was characterized by epithelial defect, including dendritic lesions (seven eyes, 25.9%), geographic ulcer (three eyes, 11.1%), and neurotrophic ulcer (two eyes, 7.4%), associated with stromal involvement in 12 cases. Six cases with stromal reactivation, including disciform keratitis (two eyes, 7.4%), immune ring (three eyes, 11.1%), and ghost vessel (one eye, 3.7%), presented no epithelial defect. Active anterior uveitis with keratic precipitates was found in 15 cases. Demodex blepharitis was diagnosed with cylindrical dandruff along their lashes in all patients. Other ocular findings include meibomian gland dysfunction (15 eyes, 55.6%), mal-aligned lashes (eight eyes, 29.6%), telangiectasia (14 eyes, 51.9%), conjunctivitis (18 eyes, 66.7%), and ocular rosacea (three eyes, 11.1%). Initial unstable clinical presentations showed deterioration of corneal melting into descemetocele, corneal perforation, recalcitrant stromal infiltration/uveitis, and uncontrollable IOP, despite antiherpetic medication. After treatment of Demodex blepharitis, infestation was under control, followed by subjective improvement of ocular symptoms and a stable clinical outcome.Conclusion: Ocular demodicosis should be considered in patients with unstable recurrent herpetic keratitis. A prompt diagnosis and appropriate treatment may curb the progression of herpetic corneal infection.Keywords: blepharitis, Demodex mites, herpetic keratitis, ocular demodicosis
format article
author Hung KH
Lan YH
Lin JY
Kang EYC
Tan HY
Chen HC
Hsiao CH
Yeh LK
author_facet Hung KH
Lan YH
Lin JY
Kang EYC
Tan HY
Chen HC
Hsiao CH
Yeh LK
author_sort Hung KH
title Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis
title_short Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis
title_full Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis
title_fullStr Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis
title_full_unstemmed Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis
title_sort potential role and significance of ocular demodicosis in patients with concomitant refractory herpetic keratitis
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/52f4190773564fe0ac2757212fc5e160
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