Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is seeded within the first 2 days after infection.

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Autores principales:	James B. Whitney, So-Yon Lim, Christa E. Osuna, Jessica L. Kublin, Elsa Chen, Gyeol Yoon, Po-Ting Liu, Peter Abbink, Erica N. Borducci, Alison Hill, Mark G. Lewis, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52f46cb5b9da47d5be04a0ba3ac32ed1
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spelling	oai:doaj.org-article:52f46cb5b9da47d5be04a0ba3ac32ed12021-12-02T13:23:48ZPrevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy10.1038/s41467-018-07881-92041-1723https://doaj.org/article/52f46cb5b9da47d5be04a0ba3ac32ed12018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07881-9https://doaj.org/toc/2041-1723The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is seeded within the first 2 days after infection.James B. WhitneySo-Yon LimChrista E. OsunaJessica L. KublinElsa ChenGyeol YoonPo-Ting LiuPeter AbbinkErica N. BorducciAlison HillMark G. LewisRomas GeleziunasMerlin L. RobbNelson L. MichaelDan H. BarouchNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James B. Whitney So-Yon Lim Christa E. Osuna Jessica L. Kublin Elsa Chen Gyeol Yoon Po-Ting Liu Peter Abbink Erica N. Borducci Alison Hill Mark G. Lewis Romas Geleziunas Merlin L. Robb Nelson L. Michael Dan H. Barouch Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
description	The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is seeded within the first 2 days after infection.
format	article
author	James B. Whitney So-Yon Lim Christa E. Osuna Jessica L. Kublin Elsa Chen Gyeol Yoon Po-Ting Liu Peter Abbink Erica N. Borducci Alison Hill Mark G. Lewis Romas Geleziunas Merlin L. Robb Nelson L. Michael Dan H. Barouch
author_facet	James B. Whitney So-Yon Lim Christa E. Osuna Jessica L. Kublin Elsa Chen Gyeol Yoon Po-Ting Liu Peter Abbink Erica N. Borducci Alison Hill Mark G. Lewis Romas Geleziunas Merlin L. Robb Nelson L. Michael Dan H. Barouch
author_sort	James B. Whitney
title	Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_short	Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_full	Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_fullStr	Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_full_unstemmed	Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_sort	prevention of sivmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/52f46cb5b9da47d5be04a0ba3ac32ed1
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Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

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