Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is seeded within the first 2 days after infection.
Enregistré dans:
Auteurs principaux: | James B. Whitney, So-Yon Lim, Christa E. Osuna, Jessica L. Kublin, Elsa Chen, Gyeol Yoon, Po-Ting Liu, Peter Abbink, Erica N. Borducci, Alison Hill, Mark G. Lewis, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/52f46cb5b9da47d5be04a0ba3ac32ed1 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
par: Shaheed A. Abdulhaqq, et autres
Publié: (2019) -
Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques
par: Celina M. Abreu, et autres
Publié: (2019) -
Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation
par: Po-Ting Liu, et autres
Publié: (2020) -
Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
par: Brandon F. Keele, et autres
Publié: (2017) -
Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus
par: Travis K. Warren, et autres
Publié: (2021)