Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now

Personalized regenerative medicine and biomedical research have been galvanized and revolutionized by human pluripotent stem cells in combination with recent advances in genomics, artificial intelligence, and genome engineering. More recently, we have witnessed the unprecedented breakthrough life-sa...

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Autores principales:	Michael Simeon, Seema Dangwal, Agapios Sachinidis, Michael Xavier Doss
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	embryonic stem cells pluripotent stem cells genomics artificial intelligence cardiovascular research cell replacement therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/52fa32cccbd646dc8d42803f6f5e79a8
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spelling	oai:doaj.org-article:52fa32cccbd646dc8d42803f6f5e79a82021-11-25T17:11:36ZApplication of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now10.3390/cells101131122073-4409https://doaj.org/article/52fa32cccbd646dc8d42803f6f5e79a82021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3112https://doaj.org/toc/2073-4409Personalized regenerative medicine and biomedical research have been galvanized and revolutionized by human pluripotent stem cells in combination with recent advances in genomics, artificial intelligence, and genome engineering. More recently, we have witnessed the unprecedented breakthrough life-saving translation of mRNA-based vaccines for COVID-19 to contain the global pandemic and the investment in billions of US dollars in space exploration projects and the blooming space-tourism industry fueled by the latest reusable space vessels. Now, it is time to examine where the translation of pluripotent stem cell research stands currently, which has been touted for more than the last two decades to cure and treat millions of patients with severe debilitating degenerative diseases and tissue injuries. This review attempts to highlight the accomplishments of pluripotent stem cell research together with cutting-edge genomics and genome editing tools and, also, the promises that have still not been transformed into clinical applications, with cardiovascular research as a case example. This review also brings to our attention the scientific and socioeconomic challenges that need to be effectively addressed to see the full potential of pluripotent stem cells at the clinical bedside.Michael SimeonSeema DangwalAgapios SachinidisMichael Xavier DossMDPI AGarticleembryonic stem cellspluripotent stem cellsgenomicsartificial intelligencecardiovascular researchcell replacement therapyBiology (General)QH301-705.5ENCells, Vol 10, Iss 3112, p 3112 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	embryonic stem cells pluripotent stem cells genomics artificial intelligence cardiovascular research cell replacement therapy Biology (General) QH301-705.5
spellingShingle	embryonic stem cells pluripotent stem cells genomics artificial intelligence cardiovascular research cell replacement therapy Biology (General) QH301-705.5 Michael Simeon Seema Dangwal Agapios Sachinidis Michael Xavier Doss Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
description	Personalized regenerative medicine and biomedical research have been galvanized and revolutionized by human pluripotent stem cells in combination with recent advances in genomics, artificial intelligence, and genome engineering. More recently, we have witnessed the unprecedented breakthrough life-saving translation of mRNA-based vaccines for COVID-19 to contain the global pandemic and the investment in billions of US dollars in space exploration projects and the blooming space-tourism industry fueled by the latest reusable space vessels. Now, it is time to examine where the translation of pluripotent stem cell research stands currently, which has been touted for more than the last two decades to cure and treat millions of patients with severe debilitating degenerative diseases and tissue injuries. This review attempts to highlight the accomplishments of pluripotent stem cell research together with cutting-edge genomics and genome editing tools and, also, the promises that have still not been transformed into clinical applications, with cardiovascular research as a case example. This review also brings to our attention the scientific and socioeconomic challenges that need to be effectively addressed to see the full potential of pluripotent stem cells at the clinical bedside.
format	article
author	Michael Simeon Seema Dangwal Agapios Sachinidis Michael Xavier Doss
author_facet	Michael Simeon Seema Dangwal Agapios Sachinidis Michael Xavier Doss
author_sort	Michael Simeon
title	Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
title_short	Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
title_full	Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
title_fullStr	Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
title_full_unstemmed	Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
title_sort	application of the pluripotent stem cells and genomics in cardiovascular research—what we have learnt and not learnt until now
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/52fa32cccbd646dc8d42803f6f5e79a8
work_keys_str_mv	AT michaelsimeon applicationofthepluripotentstemcellsandgenomicsincardiovascularresearchwhatwehavelearntandnotlearntuntilnow AT seemadangwal applicationofthepluripotentstemcellsandgenomicsincardiovascularresearchwhatwehavelearntandnotlearntuntilnow AT agapiossachinidis applicationofthepluripotentstemcellsandgenomicsincardiovascularresearchwhatwehavelearntandnotlearntuntilnow AT michaelxavierdoss applicationofthepluripotentstemcellsandgenomicsincardiovascularresearchwhatwehavelearntandnotlearntuntilnow
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Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now

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