Fluid Therapy in Perioperative Setting in Children

Background The composition of the ideal fluid for children is not standardized and there is a wide variation in clinical practice. To study the safety and impact of routinely used fluids in the electrolyte and acid-base balance. Methods We conducted an exploratory, prospective, randomised, contr...

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Autores principales:	Sofia Cochito Sousa, Francisco Sousa, Sara Vaz, Francisco Abecasis
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Portuguesa de Pediatria 2021
Materias:	Pediatrics RJ1-570 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/52fa77d2c94547beb335d0fa06dfc097
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spelling	oai:doaj.org-article:52fa77d2c94547beb335d0fa06dfc0972021-11-04T15:21:18ZFluid Therapy in Perioperative Setting in Children2184-33332184-4453https://doaj.org/article/52fa77d2c94547beb335d0fa06dfc0972021-11-01T00:00:00Zhttps://pjp.spp.pt/article/view/21917https://doaj.org/toc/2184-3333https://doaj.org/toc/2184-4453 Background The composition of the ideal fluid for children is not standardized and there is a wide variation in clinical practice. To study the safety and impact of routinely used fluids in the electrolyte and acid-base balance. Methods We conducted an exploratory, prospective, randomised, controlled trial of children aged between 28 days and 17 years undergoing elective surgery in a tertiary care university affiliated hospital in Portugal. Children received either 0.45% saline solution, 0.9% saline solution or Plasma-Lyte. Blood samples were obtained in three different moments: baseline, at the end of the surgery and in the morning after surgery. The main outcome was to evaluate the safety and efficacy of Plasma-Lyte. Results 65 children were studied with a median age of 10.0 years and a predominance of male gender (78%). On the third sample, 0.45% saline group presented lower sodium values (p=0.004) and the 0.9% saline group more negative base excess values (p=0.035). In 0.9% saline group chloride values increased over time (p=0.003) and median base excess in the second sample was within the acidosis range: -2,45 (-3.78,-0.18)mmol/L. There were very few electrolyte and acid-base disorders and none of clinical significance. Discussion and conclusion This trial demonstrated that the perioperative fluids studied were all safe. 0.45% saline solution was associated with lower sodium values and 0.9% saline solution with more negative base excess. However, the differences between groups were small, without important electrolyte disorders. In healthy children all three solutions can be used, depending on costs, availability and local policy. Sofia Cochito SousaFrancisco SousaSara VazFrancisco AbecasisSociedade Portuguesa de PediatriaarticlePediatricsRJ1-570Medicine (General)R5-920ENPTPortuguese Journal of Pediatrics , Vol 52, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Pediatrics RJ1-570 Medicine (General) R5-920
spellingShingle	Pediatrics RJ1-570 Medicine (General) R5-920 Sofia Cochito Sousa Francisco Sousa Sara Vaz Francisco Abecasis Fluid Therapy in Perioperative Setting in Children
description	Background The composition of the ideal fluid for children is not standardized and there is a wide variation in clinical practice. To study the safety and impact of routinely used fluids in the electrolyte and acid-base balance. Methods We conducted an exploratory, prospective, randomised, controlled trial of children aged between 28 days and 17 years undergoing elective surgery in a tertiary care university affiliated hospital in Portugal. Children received either 0.45% saline solution, 0.9% saline solution or Plasma-Lyte. Blood samples were obtained in three different moments: baseline, at the end of the surgery and in the morning after surgery. The main outcome was to evaluate the safety and efficacy of Plasma-Lyte. Results 65 children were studied with a median age of 10.0 years and a predominance of male gender (78%). On the third sample, 0.45% saline group presented lower sodium values (p=0.004) and the 0.9% saline group more negative base excess values (p=0.035). In 0.9% saline group chloride values increased over time (p=0.003) and median base excess in the second sample was within the acidosis range: -2,45 (-3.78,-0.18)mmol/L. There were very few electrolyte and acid-base disorders and none of clinical significance. Discussion and conclusion This trial demonstrated that the perioperative fluids studied were all safe. 0.45% saline solution was associated with lower sodium values and 0.9% saline solution with more negative base excess. However, the differences between groups were small, without important electrolyte disorders. In healthy children all three solutions can be used, depending on costs, availability and local policy.
format	article
author	Sofia Cochito Sousa Francisco Sousa Sara Vaz Francisco Abecasis
author_facet	Sofia Cochito Sousa Francisco Sousa Sara Vaz Francisco Abecasis
author_sort	Sofia Cochito Sousa
title	Fluid Therapy in Perioperative Setting in Children
title_short	Fluid Therapy in Perioperative Setting in Children
title_full	Fluid Therapy in Perioperative Setting in Children
title_fullStr	Fluid Therapy in Perioperative Setting in Children
title_full_unstemmed	Fluid Therapy in Perioperative Setting in Children
title_sort	fluid therapy in perioperative setting in children
publisher	Sociedade Portuguesa de Pediatria
publishDate	2021
url	https://doaj.org/article/52fa77d2c94547beb335d0fa06dfc097
work_keys_str_mv	AT sofiacochitosousa fluidtherapyinperioperativesettinginchildren AT franciscosousa fluidtherapyinperioperativesettinginchildren AT saravaz fluidtherapyinperioperativesettinginchildren AT franciscoabecasis fluidtherapyinperioperativesettinginchildren
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Fluid Therapy in Perioperative Setting in Children

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