The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis

Neutrophils play a vital role in the formation of arterial, venous and cancer-related thrombosis. Recent studies have shown that in a process known as NETosis, neutrophils release proteins and enzymes complexed to DNA fibers, collectively called neutrophil extracellular traps (NETs). Although NETs w...

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Autores principales:	Yilu Zhou, Weimin Tao, Fuyi Shen, Weijia Du, Zhendong Xu, Zhiqiang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neutrophil neutrophil extracellular traps thrombosis deep vein thrombosis (DVT) cancer thrombosis Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/52ff522170b141fdbe63fa70ed7dcf67
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spelling	oai:doaj.org-article:52ff522170b141fdbe63fa70ed7dcf672021-12-02T09:21:49ZThe Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis2297-055X10.3389/fcvm.2021.786387https://doaj.org/article/52ff522170b141fdbe63fa70ed7dcf672021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.786387/fullhttps://doaj.org/toc/2297-055XNeutrophils play a vital role in the formation of arterial, venous and cancer-related thrombosis. Recent studies have shown that in a process known as NETosis, neutrophils release proteins and enzymes complexed to DNA fibers, collectively called neutrophil extracellular traps (NETs). Although NETs were originally described as a way for the host to capture and kill bacteria, current knowledge indicates that NETs also play an important role in thrombosis. According to recent studies, the destruction of vascular microenvironmental homeostasis and excessive NET formation lead to pathological thrombosis. In vitro experiments have found that NETs provide skeletal support for platelets, red blood cells and procoagulant molecules to promote thrombosis. The protein components contained in NETs activate the endogenous coagulation pathway to promote thrombosis. Therefore, NETs play an important role in the formation of arterial thrombosis, venous thrombosis and cancer-related thrombosis. This review will systematically summarize and explain the study of NETs in thrombosis in animal models and in vivo experiments to provide new targets for thrombosis prevention and treatment.Yilu ZhouWeimin TaoFuyi ShenWeijia DuZhendong XuZhiqiang LiuFrontiers Media S.A.articleneutrophilneutrophil extracellular trapsthrombosisdeep vein thrombosis (DVT)cancer thrombosisDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophil neutrophil extracellular traps thrombosis deep vein thrombosis (DVT) cancer thrombosis Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	neutrophil neutrophil extracellular traps thrombosis deep vein thrombosis (DVT) cancer thrombosis Diseases of the circulatory (Cardiovascular) system RC666-701 Yilu Zhou Weimin Tao Fuyi Shen Weijia Du Zhendong Xu Zhiqiang Liu The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis
description	Neutrophils play a vital role in the formation of arterial, venous and cancer-related thrombosis. Recent studies have shown that in a process known as NETosis, neutrophils release proteins and enzymes complexed to DNA fibers, collectively called neutrophil extracellular traps (NETs). Although NETs were originally described as a way for the host to capture and kill bacteria, current knowledge indicates that NETs also play an important role in thrombosis. According to recent studies, the destruction of vascular microenvironmental homeostasis and excessive NET formation lead to pathological thrombosis. In vitro experiments have found that NETs provide skeletal support for platelets, red blood cells and procoagulant molecules to promote thrombosis. The protein components contained in NETs activate the endogenous coagulation pathway to promote thrombosis. Therefore, NETs play an important role in the formation of arterial thrombosis, venous thrombosis and cancer-related thrombosis. This review will systematically summarize and explain the study of NETs in thrombosis in animal models and in vivo experiments to provide new targets for thrombosis prevention and treatment.
format	article
author	Yilu Zhou Weimin Tao Fuyi Shen Weijia Du Zhendong Xu Zhiqiang Liu
author_facet	Yilu Zhou Weimin Tao Fuyi Shen Weijia Du Zhendong Xu Zhiqiang Liu
author_sort	Yilu Zhou
title	The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis
title_short	The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis
title_full	The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis
title_fullStr	The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis
title_full_unstemmed	The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis
title_sort	emerging role of neutrophil extracellular traps in arterial, venous and cancer-associated thrombosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/52ff522170b141fdbe63fa70ed7dcf67
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The Emerging Role of Neutrophil Extracellular Traps in Arterial, Venous and Cancer-Associated Thrombosis

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