Structures and Functional Diversities of ASFV Proteins

African swine fever virus (ASFV), the causative pathogen of the recent ASF epidemic, is a highly contagious double-stranded DNA virus. Its genome is in the range of 170~193 kbp and encodes 68 structural proteins and over 100 non-structural proteins. Its high pathogenicity strains cause nearly 100% m...

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Autores principales:	Guoguo Wang, Mengjia Xie, Wei Wu, Zhongzhou Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	African swine fever virus ASFV structures survival AP endonuclease dUTPases Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/53001910f27a456dbbbfe9a7ea628bea
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spelling	oai:doaj.org-article:53001910f27a456dbbbfe9a7ea628bea2021-11-25T19:12:26ZStructures and Functional Diversities of ASFV Proteins10.3390/v131121241999-4915https://doaj.org/article/53001910f27a456dbbbfe9a7ea628bea2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2124https://doaj.org/toc/1999-4915African swine fever virus (ASFV), the causative pathogen of the recent ASF epidemic, is a highly contagious double-stranded DNA virus. Its genome is in the range of 170~193 kbp and encodes 68 structural proteins and over 100 non-structural proteins. Its high pathogenicity strains cause nearly 100% mortality in swine. Consisting of four layers of protein shells and an inner genome, its structure is obviously more complicated than many other viruses, and its multi-layered structures play different kinds of roles in ASFV replication and survival. Each layer possesses many proteins, but very few of the proteins have been investigated at a structural level. Here, we concluded all the ASFV proteins whose structures were unveiled, and explained their functions from the view of structures. Those structures include ASFV AP endonuclease, dUTPases (E165R), pS273R protease, core shell proteins p15 and p35, non-structural proteins pA151R, pNP868R (RNA guanylyltransferase), major capsid protein p72 (gene <i>B646L</i>), Bcl-2-like protein A179L, histone-like protein pA104R, sulfhydryl oxidase pB119L, polymerase X and ligase. These novel structural features, diverse functions, and complex molecular mechanisms promote ASFV to escape the host immune system easily and make this large virus difficult to control.Guoguo WangMengjia XieWei WuZhongzhou ChenMDPI AGarticleAfrican swine fever virusASFVstructuressurvivalAP endonucleasedUTPasesMicrobiologyQR1-502ENViruses, Vol 13, Iss 2124, p 2124 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	African swine fever virus ASFV structures survival AP endonuclease dUTPases Microbiology QR1-502
spellingShingle	African swine fever virus ASFV structures survival AP endonuclease dUTPases Microbiology QR1-502 Guoguo Wang Mengjia Xie Wei Wu Zhongzhou Chen Structures and Functional Diversities of ASFV Proteins
description	African swine fever virus (ASFV), the causative pathogen of the recent ASF epidemic, is a highly contagious double-stranded DNA virus. Its genome is in the range of 170~193 kbp and encodes 68 structural proteins and over 100 non-structural proteins. Its high pathogenicity strains cause nearly 100% mortality in swine. Consisting of four layers of protein shells and an inner genome, its structure is obviously more complicated than many other viruses, and its multi-layered structures play different kinds of roles in ASFV replication and survival. Each layer possesses many proteins, but very few of the proteins have been investigated at a structural level. Here, we concluded all the ASFV proteins whose structures were unveiled, and explained their functions from the view of structures. Those structures include ASFV AP endonuclease, dUTPases (E165R), pS273R protease, core shell proteins p15 and p35, non-structural proteins pA151R, pNP868R (RNA guanylyltransferase), major capsid protein p72 (gene <i>B646L</i>), Bcl-2-like protein A179L, histone-like protein pA104R, sulfhydryl oxidase pB119L, polymerase X and ligase. These novel structural features, diverse functions, and complex molecular mechanisms promote ASFV to escape the host immune system easily and make this large virus difficult to control.
format	article
author	Guoguo Wang Mengjia Xie Wei Wu Zhongzhou Chen
author_facet	Guoguo Wang Mengjia Xie Wei Wu Zhongzhou Chen
author_sort	Guoguo Wang
title	Structures and Functional Diversities of ASFV Proteins
title_short	Structures and Functional Diversities of ASFV Proteins
title_full	Structures and Functional Diversities of ASFV Proteins
title_fullStr	Structures and Functional Diversities of ASFV Proteins
title_full_unstemmed	Structures and Functional Diversities of ASFV Proteins
title_sort	structures and functional diversities of asfv proteins
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/53001910f27a456dbbbfe9a7ea628bea
work_keys_str_mv	AT guoguowang structuresandfunctionaldiversitiesofasfvproteins AT mengjiaxie structuresandfunctionaldiversitiesofasfvproteins AT weiwu structuresandfunctionaldiversitiesofasfvproteins AT zhongzhouchen structuresandfunctionaldiversitiesofasfvproteins
_version_	1718410155736956928

Structures and Functional Diversities of ASFV Proteins

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