A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi

Abstract Component-based Chinese medicine (CCM) is derived from traditional Chinese medicine but produced with modern pharmaceutical standard and clearer clinical indications. However, it still faces challenges of defining individual component contribution in the complex formula. Using QiShenYiQi (Q...

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Autores principales:	Jiahui Yu, Wen Zhang, Yiqian Zhang, Yadong Wang, Boli Zhang, Guanwei Fan, Yan Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53018215739a4e239277851228ba238b
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spelling	oai:doaj.org-article:53018215739a4e239277851228ba238b2021-12-02T12:32:20ZA critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi10.1038/s41598-017-07659-x2045-2322https://doaj.org/article/53018215739a4e239277851228ba238b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07659-xhttps://doaj.org/toc/2045-2322Abstract Component-based Chinese medicine (CCM) is derived from traditional Chinese medicine but produced with modern pharmaceutical standard and clearer clinical indications. However, it still faces challenges of defining individual component contribution in the complex formula. Using QiShenYiQi (QSYQ) as a model CCM, we investigated the role of Dalbergia odorifera (DO), an herbal component, in preventing myocardial damage. We showed that in vitro, QSYQ exerted considerable protective activities on cardiomyocytes from H2O2-induced mitochondrial dysfunction with or without DO. However, in isolated rat hearts, myocardial protection by QSYQ was significantly weakened without DO. In everted gut sac model, DO significantly enhanced absorption of the major QSYQ ingredients in different regions of rat intestine. Finally, in in vivo mouse model of doxorubicin (DOX)-induced myocardial damage, only QSYQ, but not QiShenYiQi without DO (QSYQ-DO), exerted a full protection. Taken together, our results showed that instead of directly contributing to the myocardial protection, Dalbergia odorifera facilitates the major active ingredients absorption and increases their efficacy, eventually enhancing the in vivo potency of QSYQ. These findings may shed new lights on our understanding of the prescription compatibility theory, as well as the impacts of “courier herbs” in component-based Chinese medicine.Jiahui YuWen ZhangYiqian ZhangYadong WangBoli ZhangGuanwei FanYan ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiahui Yu Wen Zhang Yiqian Zhang Yadong Wang Boli Zhang Guanwei Fan Yan Zhu A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
description	Abstract Component-based Chinese medicine (CCM) is derived from traditional Chinese medicine but produced with modern pharmaceutical standard and clearer clinical indications. However, it still faces challenges of defining individual component contribution in the complex formula. Using QiShenYiQi (QSYQ) as a model CCM, we investigated the role of Dalbergia odorifera (DO), an herbal component, in preventing myocardial damage. We showed that in vitro, QSYQ exerted considerable protective activities on cardiomyocytes from H2O2-induced mitochondrial dysfunction with or without DO. However, in isolated rat hearts, myocardial protection by QSYQ was significantly weakened without DO. In everted gut sac model, DO significantly enhanced absorption of the major QSYQ ingredients in different regions of rat intestine. Finally, in in vivo mouse model of doxorubicin (DOX)-induced myocardial damage, only QSYQ, but not QiShenYiQi without DO (QSYQ-DO), exerted a full protection. Taken together, our results showed that instead of directly contributing to the myocardial protection, Dalbergia odorifera facilitates the major active ingredients absorption and increases their efficacy, eventually enhancing the in vivo potency of QSYQ. These findings may shed new lights on our understanding of the prescription compatibility theory, as well as the impacts of “courier herbs” in component-based Chinese medicine.
format	article
author	Jiahui Yu Wen Zhang Yiqian Zhang Yadong Wang Boli Zhang Guanwei Fan Yan Zhu
author_facet	Jiahui Yu Wen Zhang Yiqian Zhang Yadong Wang Boli Zhang Guanwei Fan Yan Zhu
author_sort	Jiahui Yu
title	A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_short	A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_full	A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_fullStr	A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_full_unstemmed	A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
title_sort	critical courier role of volatile oils from dalbergia odorifera for cardiac protection in vivo by qishenyiqi
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/53018215739a4e239277851228ba238b
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A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi

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