Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage

ABSTRACT The role of phenotypic plasticity in the evolution of new traits is controversial due to a lack of direct evidence. Phage host range becomes plastic in the presence of restriction-modification (R-M) systems in their hosts. I modeled the evolution of phage host range in the presence of R-M s...

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Autor principal:	Colin S. Maxwell
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	bacteriophage evolution cost of plasticity genetic assimilation host range phenotypic plasticity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5304ec6087274e229899527063f48054
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spelling	oai:doaj.org-article:5304ec6087274e229899527063f480542021-11-15T15:52:18ZHypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage10.1128/mBio.00765-182150-7511https://doaj.org/article/5304ec6087274e229899527063f480542018-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00765-18https://doaj.org/toc/2150-7511ABSTRACT The role of phenotypic plasticity in the evolution of new traits is controversial due to a lack of direct evidence. Phage host range becomes plastic in the presence of restriction-modification (R-M) systems in their hosts. I modeled the evolution of phage host range in the presence of R-M systems. The model makes two main predictions. The first prediction is that the offspring of the first phage to gain a new methylation pattern by infecting a new host make up a disproportionate fraction of the subsequent specialist population, indicating that the plastically produced phenotype is highly predictive of evolutionary outcome. The second prediction is that the first phage to gain this pattern is not always genetically distinct from other phages in the population. Taken together, these results suggest that plasticity could play a causal role on par with mutation during the evolution of phage host range. This uniquely tractable system could enable the first direct test of “plasticity first” evolution.Colin S. MaxwellAmerican Society for Microbiologyarticlebacteriophage evolutioncost of plasticitygenetic assimilationhost rangephenotypic plasticityMicrobiologyQR1-502ENmBio, Vol 9, Iss 6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacteriophage evolution cost of plasticity genetic assimilation host range phenotypic plasticity Microbiology QR1-502
spellingShingle	bacteriophage evolution cost of plasticity genetic assimilation host range phenotypic plasticity Microbiology QR1-502 Colin S. Maxwell Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
description	ABSTRACT The role of phenotypic plasticity in the evolution of new traits is controversial due to a lack of direct evidence. Phage host range becomes plastic in the presence of restriction-modification (R-M) systems in their hosts. I modeled the evolution of phage host range in the presence of R-M systems. The model makes two main predictions. The first prediction is that the offspring of the first phage to gain a new methylation pattern by infecting a new host make up a disproportionate fraction of the subsequent specialist population, indicating that the plastically produced phenotype is highly predictive of evolutionary outcome. The second prediction is that the first phage to gain this pattern is not always genetically distinct from other phages in the population. Taken together, these results suggest that plasticity could play a causal role on par with mutation during the evolution of phage host range. This uniquely tractable system could enable the first direct test of “plasticity first” evolution.
format	article
author	Colin S. Maxwell
author_facet	Colin S. Maxwell
author_sort	Colin S. Maxwell
title	Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_short	Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_full	Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_fullStr	Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_full_unstemmed	Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_sort	hypothesis: a plastically produced phenotype predicts host specialization and can precede subsequent mutations in bacteriophage
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/5304ec6087274e229899527063f48054
work_keys_str_mv	AT colinsmaxwell hypothesisaplasticallyproducedphenotypepredictshostspecializationandcanprecedesubsequentmutationsinbacteriophage
_version_	1718427275370692608

Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage

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