Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage

ABSTRACT The role of phenotypic plasticity in the evolution of new traits is controversial due to a lack of direct evidence. Phage host range becomes plastic in the presence of restriction-modification (R-M) systems in their hosts. I modeled the evolution of phage host range in the presence of R-M s...

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Autor principal: Colin S. Maxwell
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Publicado: American Society for Microbiology 2018
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spelling oai:doaj.org-article:5304ec6087274e229899527063f480542021-11-15T15:52:18ZHypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage10.1128/mBio.00765-182150-7511https://doaj.org/article/5304ec6087274e229899527063f480542018-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00765-18https://doaj.org/toc/2150-7511ABSTRACT The role of phenotypic plasticity in the evolution of new traits is controversial due to a lack of direct evidence. Phage host range becomes plastic in the presence of restriction-modification (R-M) systems in their hosts. I modeled the evolution of phage host range in the presence of R-M systems. The model makes two main predictions. The first prediction is that the offspring of the first phage to gain a new methylation pattern by infecting a new host make up a disproportionate fraction of the subsequent specialist population, indicating that the plastically produced phenotype is highly predictive of evolutionary outcome. The second prediction is that the first phage to gain this pattern is not always genetically distinct from other phages in the population. Taken together, these results suggest that plasticity could play a causal role on par with mutation during the evolution of phage host range. This uniquely tractable system could enable the first direct test of “plasticity first” evolution.Colin S. MaxwellAmerican Society for Microbiologyarticlebacteriophage evolutioncost of plasticitygenetic assimilationhost rangephenotypic plasticityMicrobiologyQR1-502ENmBio, Vol 9, Iss 6 (2018)
institution DOAJ
collection DOAJ
language EN
topic bacteriophage evolution
cost of plasticity
genetic assimilation
host range
phenotypic plasticity
Microbiology
QR1-502
spellingShingle bacteriophage evolution
cost of plasticity
genetic assimilation
host range
phenotypic plasticity
Microbiology
QR1-502
Colin S. Maxwell
Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
description ABSTRACT The role of phenotypic plasticity in the evolution of new traits is controversial due to a lack of direct evidence. Phage host range becomes plastic in the presence of restriction-modification (R-M) systems in their hosts. I modeled the evolution of phage host range in the presence of R-M systems. The model makes two main predictions. The first prediction is that the offspring of the first phage to gain a new methylation pattern by infecting a new host make up a disproportionate fraction of the subsequent specialist population, indicating that the plastically produced phenotype is highly predictive of evolutionary outcome. The second prediction is that the first phage to gain this pattern is not always genetically distinct from other phages in the population. Taken together, these results suggest that plasticity could play a causal role on par with mutation during the evolution of phage host range. This uniquely tractable system could enable the first direct test of “plasticity first” evolution.
format article
author Colin S. Maxwell
author_facet Colin S. Maxwell
author_sort Colin S. Maxwell
title Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_short Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_full Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_fullStr Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_full_unstemmed Hypothesis: a Plastically Produced Phenotype Predicts Host Specialization and Can Precede Subsequent Mutations in Bacteriophage
title_sort hypothesis: a plastically produced phenotype predicts host specialization and can precede subsequent mutations in bacteriophage
publisher American Society for Microbiology
publishDate 2018
url https://doaj.org/article/5304ec6087274e229899527063f48054
work_keys_str_mv AT colinsmaxwell hypothesisaplasticallyproducedphenotypepredictshostspecializationandcanprecedesubsequentmutationsinbacteriophage
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